A drug known as an antifungal agent selectively removes fungal pathogens from a host with little harm to the host. Classes: 1. Polyene antifungal medications: Amphotericin, nystatin, and pimaricin interact with the cell membrane's sterols (ergosterol in fungi, cholesterol in people) to create channels that allow small molecules to escape the inside of the fungal cell and enter the surrounding environment. 2. Azole antifungal medications: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes, particularly C14-demethylase, which are involved in the biosynthesis of ergosterol, a substance necessary for the structure and operation of fungal cell membranes. 3. Morpholine and allylamine antifungal medications: Squalene epoxidase is the enzyme that lylamines (naftifine, terbinafine) inhibit. At a later stage, the morpholine drug amorolfine inhibits the same pathway. 4. Antifungal Antimetabolite Drugs: Because 5-fluorocytosine is converted to 5-fluorouracil intracytoplasmically, it inhibits the synthesis of both DNA and RNA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54031 | Phaseollidin | 37831-70-2 | Phaseollidin is an antifungal compound/agent extracted from Phaseolus vulgaris L. |
|
V54021 | Phaseollidin hydrate | 76122-57-1 | Phaseollidin hydrate is the hydrated form of the antibacterial phytoalexin Phaseollidin, which has lower antifungal activity than the original Phaseollidin. |
|
V53261 | Phenazine-1-carboxylic acid | 2538-68-3 | Phenazine-1-carboxylic acid has strong antifungal activity against plant pathogenic fungi. |
|
V34807 | Phosphatase-IN-1 | 2889356-55-0 | Phosphatase-IN-1 (compound II-8) is a propranolol analogue and a phosphatidic acid phosphatase (Pah) inhibitor. |
|
V54016 | Phosphomannose isomerase | 9023-88-5 | Phosphomannose isomerase is the first enzyme involved in the GDP-Man biosynthetic pathway. |
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V41004 | Picarbutrazox | 500207-04-5 | Picarbutrazox is a potent insecticide and fungicide. |
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V52918 | Picoxystrobin | 117428-22-5 | Picoxystrobin is a major strobilurin fungicide that has been extensively used to control plant diseases. |
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V53048 | Picropodophyllone | 477-48-5 | Picropodophyllone is an aryltetrahydrofuran lignan extracted from the leaves of Podophyllum hexandrum and displays antifungal activity. |
|
V54032 | Piperanine | 23512-46-1 | Piperanine is an antifungal agent. |
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V54030 | Plumieride (Agoniadin; NSC 609065) | 511-89-7 | Plumieride is an antifungal agent. |
|
V22587 | Polygodial (Poligodial; Tadeonal) | 6754-20-7 | Polygodial (Poligodial) is an antifungal enhancer. |
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V53429 | Polyoxin D (Polyoxorim) | 22976-86-9 | Polyoxin D (Polyoxorim), a polymycin antibiotic fungicide, is a potent chitin synthetase inhibitor. |
|
V1855 | Posaconazole (SCH 56592) | 171228-49-2 | Posaconazole (also known as SCH 56592 or trade name of Noxafil) is a potent,broad-spectrum, second generation triazole antifungal compound that potently inhibits 14α-demethylation in a variety of fungi, including Candida and Aspergillus, with half maximal inhibition concentration IC50 of 0.007 μg/ml, 0.06 μg/ml, 0.2 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml respectively Posaconzole, an itraconzole derivative with fluorine replacing chlorine in the phenyl ring and hydroxylation in the side chain, binds to the heme cofactor on the active site of 14α-demethylase, which converts lanosterol to 14α-dimethy lanosterol, resulting in the disruption of the integrity and function of the fungal cell membrane and inhibition of fungal growth. |
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V53947 | Prochloraz manganese (prochloraz manganese salt) | 75747-77-2 | Prochloraz manganese is an antifungal compound/agent used in the agricultural industry. |
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V53918 | Propamocarb (propamocarb) | 24579-73-5 | Propamocarb is a systemic fungicide. |
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V56265 | Propamocarb-d7 (propamocarb-d7) | 1398065-89-8 | Propamocarb-d7 is the deuterated form of Propamocarb. |
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V52778 | Propiconazole-d3 nitrate | 2699607-26-4 | Propiconazole-d3 (nitrate) is the deuterated form of Propiconazole nitrate. |
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V56299 | Propiconazole-d7 | 1246818-14-3 | Propiconazole-d7 is the deuterated form of Propiconazole. |
|
V40023 | Protoneogracillin | 191334-50-6 | Protoneogracillin is a furosterol glycoside with inhibitory effect against the plant pathogenic fungus P. oryzae (MMDC=94.0 μM) and cytotoxic activity against K562 cancer cells (IC50=6.6 μM). |
|
V53929 | Pterolactam | 38072-88-7 | Pterolactam can be extracted from Chrysanthemum chrysanthemum. |
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