Posaconazole (also known as SCH 56592 or trade name of Noxafil) is a potent, broad-spectrum, second generation triazole antifungal compound that potently inhibits 14α-demethylation in a variety of fungi, including Candida and Aspergillus, with half maximal inhibition concentration IC50 of 0.007 μg/ml, 0.06 μg/ml, 0.2 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml respectively Posaconzole, an itraconzole derivative with fluorine replacing chlorine in the phenyl ring and hydroxylation in the side chain, binds to the heme cofactor on the active site of 14α-demethylase, which converts lanosterol to 14α-dimethy lanosterol, resulting in the disruption of the integrity and function of the fungal cell membrane and inhibition of fungal growth.
C, 63.41; H, 6.04; F, 5.42; N, 15.99; O, 9.13
|Related CAS #||
Posaconazole; Noxafil; SCH-56592; Schering 56592; Sch 56592; Schering 56592;
|HS Tariff Code||
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|Solubility (In Vitro)||
DMSO : 18.75~100 mg/mL ( 26.76~142.69 mM )
|Solubility (In Vivo)||
10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 1.88 mg/mL (2.68 mM) (Please use freshly prepared in vivo formulations for optimal results.)
|Preparing Stock Solutions||1 mg||5 mg||10 mg|
|1 mM||1.4270 mL||7.1349 mL||14.2698 mL|
|5 mM||0.2854 mL||1.4270 mL||2.8540 mL|
|10 mM||0.1427 mL||0.7135 mL||1.4270 mL|
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
In vivo formula preparation method：take μL DMSO mother liquor，join μL Corn oil，mix well and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.