In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71767 | GBR-12879 dihydrochloride | 67469-45-8 | GBR-12879 diHCl is a potent dopamine uptake inhibitor. |
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V2454 | GR 103691 | 162408-66-4 | GR 103691 is a potent and specific dopamine D3 receptor blocker (antagonist) with Ki of 0.4 nM. |
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V71717 | GSK598809 | 863680-45-9 | GSK598809 is a selective antagonist of dopamine D3 receptor (DRD3) with pKi of 8.9. |
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V22058 | Haloperidol | 52-86-8 | Haloperidol (R1625; Eukystol; HSDB-3093; Haldol; Serenace; Aloperidin) is a potent antipsychotic medication acting as adopamine D2 receptor antagonist. |
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V71742 | Haloperidol-d4 N-Oxide (haloperidol d4 (N-oxide)) | 1246815-56-4 | Haloperidol-d4 N-Oxide is the deuterium labelled form of Haloperidol. |
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V22774 | ITI-722 (Lumateperone) | 313368-91-1 | Lumateperone (ITI-722; ITI722; Caplyta) is a novel, potent, first-in-class and dual 5HT2A receptor antagonist and dopamine receptor phosphoprotein modulator (DPPM). |
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V71776 | JHW007 hydrochloride | 202645-74-7 | JHW007 HCl is the HCl of JHW007. |
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V71153 | LE 300 | 274694-98-3 | LE 300 is a potent and specific dopamine D1-like receptor antagonist (inhibitor) with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. |
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V1252 | Levodopa (L-DOPA) | 59-92-7 | Levodopa(L-DOPA, Dopar, Sinemet, Pharmacopa, Atamet, Stalevo, Madopar, Prolopa) is the L-isomer of DOPA and the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) with anti-Parkinsons disease activity. |
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V1267 | Levosulpiride (RV-12309) | 23672-07-3 | Levosulpiride (RV 12309; RV-12309; S-(-)-Sulpiride) is the S-enantiomer of sulpiride, which is a potent and selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent. |
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V1266 | Lurasidone HCl (SM-13496) | 367514-88-3 | Lurasidone HCl (SM-13496; SM 13496; trade name Latuda), the hydrochloride salt of Lurasidone, is an atypical antipsychotic drug that has been approved for the treatment of schizophrenia and bipolar disorder. |
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V71737 | Mesdopetam (IRL790) | 1403894-72-3 | Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM) with psychomotor stabilizing properties. |
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V71725 | Mesdopetam hemitartrate (IRL790 hemitartrate) | 2562346-14-7 | Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM) with psychomotor stabilizing properties. |
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V1254 | Metoclopramide HCl | 7232-21-5 | Metoclopramide HCl (Maxolon, AHR3070-C, AHR 3070-C, Metozolv, Reglan), the hydrochloride salt of Metoclopramide, is a potent and selective dopamine D2 receptor antagonist used as a medication for treating stomach and esophageal problems such as nausea and vomiting. |
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V71731 | MIF-1 TFA (Pro-Leu-Gly-NH2 TFA; Melanostatin TFA) | 35240-69-8 | MIF-1 TFA (Melanostatin) is an endogenous brain peptide and a potent allosteric modulator of dopamine receptors. |
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V37653 | ML417 | 1386162-69-1 | ML417 is a novel and selective agonist of D3 dopamine receptor, it potently promotes D3R-mediated β-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors. |
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V2705 | MPTP hydrochloride | 23007-85-4 | MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. |
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V71741 | Mulberrofuran H | 89199-99-5 | Morus lhou (ser.) is a 2-aryl benzofuran analogue found in cultivated mulberry tree (Morus lhou (ser.)). |
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V71611 | N-acetyl CCK-(26-30) amide (CCK-(26-30) (sulfated)) | 89911-69-3 | N-acetyl CCK-(26-30) amide (CCK-(26-30) (sulfated)) is a cholecystokinin (CCK) receptor blocker (antagonist). |
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V71778 | N-Despropyl Ropinirole (SKF-104557) | 106916-16-9 | N-Despropyl Ropinirole (SKF-104557) is the bioactive metabolite of the dopamine D2 receptor agonist Ropinirole. |
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