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    Metoclopramide HCl
    Metoclopramide HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1254
    CAS #: 7232-21-5Purity ≥98%

    Description: Metoclopramide HCl is a potent and selective dopamine D2 receptor antagonist. It is a medication used mostly for stomach and esophageal problems such as nausea and vomiting. It can help with emptying of the stomach in people with delayed stomach emptying due to either diabetes or following surgery, and help with gastroesophageal reflux disease. In addition, it can also used to treat migraine headaches. 

    References: Am J Emerg Med. 2015 Mar;33(3):331-7.

    Related CAS #: 364-62-5 (free base)   54143-57-6 (HCl)

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    Molecular Weight (MW)336.26
    FormulaC14H23Cl2N3O2
    CAS No.7232-21-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 67 mg/mL (199.3 mM)
    Water: N/A
    Ethanol: 67 mg/mL (199.3 mM)
    SMILES

    Chemical Name: Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-, monohydrochloride, monohydrate

    InChi Key: KJBLQGHJOCAOJP-UHFFFAOYSA-N

    InChi Code: 1S/C14H22ClN3O2.ClH.H2O/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H;1H2

    SMILES Code: O.Cl.CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC

    Synonyms

    AHR-3070-C, AHR3070-C, AHR 3070-C, Maxolon, Metoclopramide HCl, Metoclopramide hydrochloride, Metoclopramide monohydrochloride monohydrate, Metozolv, Reglan


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    In Vitro

    In vitro activity: Metoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist.

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    These protocols are for reference only. InvivoChem does not independently validate these methods.

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