Metoclopramide HCl

Alias:
Cat No.:V1254 Purity: ≥98%
Metoclopramide HCl (Maxolon, AHR3070-C, AHR 3070-C, Metozolv, Reglan), the hydrochloride salt of Metoclopramide, is a potent and selective dopamine D2 receptor antagonist used as a medication for treating stomach and esophageal problems such as nausea and vomiting.
Metoclopramide HCl Chemical Structure CAS No.: 7232-21-5
Product category: Dopamine Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
100mg
250mg
500mg
1g
2g
5g
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Other Forms of Metoclopramide HCl:

  • Metoclopramide
  • Metoclopramide hydrochloride hydrate
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Metoclopramide HCl (Maxolon, AHR3070-C, AHR 3070-C, Metozolv, Reglan), the hydrochloride salt of Metoclopramide, is a potent and selective dopamine D2 receptor antagonist used as a medication for treating stomach and esophageal problems such as nausea and vomiting. It can aid in the relief of gastroesophageal reflux disease and help those whose stomach emptying is delayed as a result of diabetes or surgery. Furthermore, it is also effective in treating migraine headaches.

Biological Activity I Assay Protocols (From Reference)
Targets
5-HT3 Receptor ( IC50 = 308 nM ); D2 Receptor ( IC50 = 483 nM )
ln Vitro

In vitro activity: Metoclopramide hydrochloride (0.01-10 μM) stimulates the release of aldosterone in perfused isolated rat zona glomerulosa cells[3].
Metoclopramide hydrochloride causes prokinesis through four different mechanisms: it inhibits D2 postsynaptic receptors, stimulates presynaptic excitatory 5-HT4 receptors, and antagonizes the presynaptic inhibition of muscarinic receptors, which increases the release of acetylcholine (ACh) from intrinsic cholinergic motor neurons[2].

ln Vivo
Metoclopramide (6.7 µg/g; once daily, subcutaneously for 50 days) During every stage of the estrous cycle, hydrochloride dramatically raises the pituitary gland's lactotroph cell count and volume[4].
Metoclopramide hydrochloride (5–40 mg/kg; intraperitoneal) causes catalepsy and antagonistic Mice's tendency to climb their cages was induced by apomorphine[5].
Metoclopramide (1.25-2.5 mg/kg; i.p.) hydrochloride induces in mice a stereotyped behavior of climbing cages[5].
Animal Protocol
Adult, virgin female mice of the Swiss EPM-1 strain
6.7 µg/g
S.c. daily for 50 days
References

[1]. Synthesis and structure-activity relationships of 4-amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonist. Chem Pharm Bull (Tokyo) . 2002 Jul;50(7):941-59.

[2]. Review article: metoclopramide and tardive dyskinesia. Aliment Pharmacol Ther. 2010 Jan;31(1):11-9.

[3]. In vivo and in vitro studies on the effect of metoclopramide on aldosterone secretion. Clin Endocrinol (Oxf). 1980 Jul;13(1):45-50.

[4]. Dose-dependent response of central dopaminergic systems to metoclopramide in mice. Indian J Exp Biol. 1997 Jun;35(6):618-22.

[5]. Effects of metoclopramide on the mouse anterior pituitary during the estrous cycle. Clinics (Sao Paulo). 2011;66(6):1101-4.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C14H23CL2N3O2
Molecular Weight
336.26
Exact Mass
335.12
Elemental Analysis
C, 50.01; H, 6.89; Cl, 21.09; N, 12.50; O, 9.52
CAS #
7232-21-5
Appearance
Solid powder
SMILES
CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.Cl
InChi Key
RVFUNJWWXKCWNS-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H22ClN3O2.ClH/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H
Chemical Name
4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride
Synonyms

AHR-3070-C; Metoclopramide HCl; Metoclopramide hydrochloride; Metoclopramide monohydrochloride monohydrate; Maxolon; AHR3070-C; AHR 3070-C; Metozolv; Reglan

HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: ~67 mg/mL (~199.3 mM)
Water: ~67 mg/mL
Ethanol: ~67 mg/mL (~199.3 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.9739 mL 14.8694 mL 29.7389 mL
5 mM 0.5948 mL 2.9739 mL 5.9478 mL
10 mM 0.2974 mL 1.4869 mL 2.9739 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

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g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02965963 Active
Recruiting
Drug: Dopamine
Drug: Metoclopramide
Drug: Placebos
Other: Rest
Health University of Alberta December 2016 Not Applicable
NCT05746377 Recruiting Drug: Metoclopramide 10mg
Drug: Saline
Upper GI Bleeding
Bleeds Gastric
Bleed Ulcer
Mercy Health System May 20, 2023 Phase 4
NCT05222646 Recruiting Drug: Metoclopramide Duration of Labour Uwakwe Emmanuel Chijioke January 3, 2022 Phase 1
NCT05102591 Recruiting Drug: Ketorolac
Drug: Metoclopramide
Drug: Placebo
Migraine Disorders University of Calgary February 22, 2022 Phase 3
NCT05533281 Recruiting Drug: tropisetron
Drug: metoclopramide
Drug: dexamethasone
Nausea and Vomiting The Second Affiliated Hospital
of Chongqing Medical University
September 15, 2022 Early Phase 1
Biological Data
  • Immunohistochemical localization of prolactin in adenohypophyseal lactotrophs in female control (Ctr) mice or mice treated with metoclopramide (HPrl) in the estrous phase. Clinics (Sao Paulo) . 2011;66(6):1101-4.
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