In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71756 | Amisulpride-d5 N-Oxide (amisulpride d5 (N-oxide)) | 1794756-15-2 | Amisulpride-d5 N-Oxide is the deuterated form of Amisulpride. |
|
V1248 | Benztropine mesylate | 132-17-2 | Benztropine mesylate (NSC-42199; ST-50997629; NSC 42199; ST 50997629; Cogentin; MLS000737056), the mesilate salt of Benztropine, is a highly potent dopamine transporter (DAT) inhibitor used for the treatment of symptoms of Parkinson's disease such as involuntary tremor and dystonia. |
|
V71768 | BP 897 | 192384-87-5 | BP 897 is a potent partial dopamine D3 receptor agonist and weak D2 receptor antagonist. |
|
V3385 | BP897 | 314776-92-6 | BP 897 is a first potent and selective agonist of dopamine D3 receptor, and a weak antagonist of dopamine D2 receptor with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. |
|
V71203 | Brexpiprazole-d8-1 (OPC-34712-d8-1) | 1427049-19-1 | Brexpiprazole-d8-1 is the deuterated form of Brexpiprazole. |
|
V17086 | Bromocriptine Mesylate (CB-154) | 22260-51-1 | Bromocriptine Mesylate(CB154) is a dopamine D2/3 agonist (with pKi of 8.05±0.2 for D2) for the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes. |
|
V17137 | Bromperidol (Impromen; R-11333) | 10457-90-6 | Bromperidol (Impromen; R11333),a butyrophenone derivative, is potent and long-term maintenance treatment for schizophrenia. |
|
V71757 | Bulbocapnine hydrochloride | 632-47-3 | Bulbocapnine HCl is an aporphine alkaloid and a dopamine receptor blocker/inhibitor. |
|
V3673 | Cariprazine | 839712-12-8 | Cariprazine (formerly known as MP-214 and RGH-188; Vraylar; Reagila) is a novel and potent antipsychotic drug that has been approved for the treatment of schizophrenia, as well as for bipolar disorder (manic/mixed and depressive episodes), and as an adjunctive agent for the treatment of major depressive disorders. |
|
V2902 | Cariprazine HCl | 1083076-69-0 | Cariprazine HCl(formerly MP-214; RGH-188; MP214; RGH188; Vraylar; Reagila), thehydrochloride salt of cariprazine, is an antipsychotic medication that has been approved for the treatment of schizophrenia, as well as for bipolar disorder (manic/mixed and depressive episodes), and as an adjunctive agent for the treatment of major depressive disorder. |
|
V71136 | Cariprazine-d6 (RGH-188-d6) | 1308278-67-2 | Cariprazine-d6 is the deuterated form of Cariprazine. |
|
V71720 | Carmoxirole hydrochloride (EMD 45609 hydrochloride) | 115092-85-8 | Carmoxirole HCl (EMD 45609 HCl) is a selective agonist that acts on peripheral dopamine D2 receptors and has antihypertensive activity in vivo. |
|
V1249 | Chlorpromazine HCl | 69-09-0 | Chlorpromazine HCl (Promacid; Chloractil; Klorpromex; Fenactil; Largactil; Propaphenin; Sonazine; Thorazine), the Hydrochloride salt form of chlorpromazine, is a potent dopamine and potassium channel inhibitor used as an antipsychotic medication for the treatment of psychotic disorders such as schizophrenia. |
|
V1259 | Chlorprothixene | 113-59-7 | Chlorprothixene (Paxyl; Rentovet; Truxal; Ro 4-0403; N-714; MK-184; Taractan; Tarasan), an typical antipsychotic drug of the thioxanthene class, is an antagonist of dopamine and histamine receptors with potential antipsychotic, sedative and antiemetic activity. |
|
V18228 | Chlorprothixene HCl | 6469-93-8 | ChlorprothixeneHCl is a typical antipsychotic drug of the thioxanthene class and an antagonist of dopamine and histamine receptors such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively. |
|
V9293 | Clozapine N-oxide | 34233-69-7 | Clozapine N-oxide is a major metabolite of Clozapine and an agonist of human designer muscarinic receptors (DREADDs). |
|
V71723 | CY 208-243 | 100999-26-6 | CY 208-243 is a selective dopamine D1 receptor agonist (activator) with anti-Parkinson's disease (PD) activity. |
|
V71770 | Cyclo(glycyl-L-leucyl) (Cyclo(glycyl-L-leucyl); Cyclo(leu-gly)) | 5845-67-0 | Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)) is a neuropeptide that downregulates dopamine (DA) receptors and attenuates dopaminergic hypersensitivity. |
|
V71754 | D4R antagonis-2 | 2846077-70-9 | D4R antagonist-2 is a potent and specific D4R antagonist (inhibitor) with IC50 of 6.87 µM. |
|
V71739 | D4R antagonist-1 | 2846077-19-6 | D4R antagonist-1 is a potent and specific D4R antagonist (inhibitor) with IC50 of 6.87 µM. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
