In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71747 | NGB 2904 hydrochloride | 189061-11-8 | NGB 2904 HCl is a specific, orally bioactive and BBB (blood-brain barrier) permeable (penetrable) dopamine D3 receptor antagonist (inhibitor) with a Ki of 1.4 nM. |
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V26431 | NGB2904 HCl | 189060-98-8 | NGB2904 HCl (NGB-2904) is a novel,selective, orally bioactive antagonist ofdopamine D3 receptor with the potential tobe used for cocaine addiction. |
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V1263 | Nilvadipine (ARC029; FR34235; FK-235) | 75530-68-6 | Nilvadipine (formerly ARC-029; FR34235, FK235; ARC029; FR-34235; FK-235; Escor, Nivadil) is a potent calcium channel blocker (CCB) with potential antihypertensive activity. |
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V17015 | Nomifensine | 24526-64-5 | Nomifensine is an isoquinoline analoguethat prevents dopamine reuptake into synaptosomes. |
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V20614 | Nomifensine Maleate | 32795-47-4 | Nomifensine Maleate, the maleate salt of nomifensine, is a novel, potent and selective dopamine uptake inhibitor interacting with the dopamine transporter at a site different from that of cocaine; antidepressan. |
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V71758 | Nomifensine-d3 maleate | 1795140-41-8 | Nomifensine-d3 (maleate) is the deuterium labelled form of Nomifensine maleate. |
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V71749 | NPEC-caged-dopamine | 1257326-23-0 | NPEC-caged-dopamine is dopamine wrapped in NEPC. |
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V71724 | Odapipam (NNC 756) | 131796-63-9 | Odapipam (NNC 756) is a selective, high-affinity benzazepine dopamine D1 receptor antagonist (inhibitor) with a Kd of 0.18 nM. |
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V70059 | Onzigolide (BIM-23A760; TBR-760) | 778630-77-6 | Onzigolide (BIM-23A760), a chimeric dopamine somatostatin compound, operates at DA2-type (D2R) and SST2-type (SSTR2) receptors. |
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V1260 | Paliperidone | 144598-75-4 | Paliperidone (Invega; Invega Sustenna; Invega Sustenna; 9-hydroxyrisperidone), the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist used for the treatment of schizophrenia. |
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V4826 | Paliperidone Palmitate | 199739-10-1 | Paliperidone palmitate (RO-92670; 9-Hydroxyrisperidone palmitate; RO92670) is a novel and potent dopamine antagonist and 5-HT2A antagonist that belongs to the atypical antipsychotic class of medications. |
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V71738 | Paliperidone-d4 (Paliperidone d4) | 1020719-55-4 | Paliperidone-d4 is the deuterium labelled form of Paliperidone. |
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V0039 | PD 128907 HCl | 112960-16-4 | PD 128907 HCl (PD-128907) is a novel, potent and selective dopamine D3 receptor agonist with EC50 of 0.64 nM, it exhibits 53-fold selectivity over dopamine D2 receptor. |
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V71762 | PD 168568 | 210688-56-5 | PD 168568 is an orally bioavailable dopamine receptor D4 (DRD4) antagonist. |
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V4808 | PD-168077 maleate | 630117-19-0 | PD-168077 maleate, the maleate salt of PD168077, is a novel, potent, centrally active and selective dopamine D4 receptor agonist with a Ki of 9 nM. |
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V1270 | Penfluridol (R-16341) | 26864-56-2 | Penfluridol (formerly TLP-607; McN-JR-16341; R-16341; Acemap; Semap)is a 1st generation, long-acting and diphenylbutylpiperidine-based antipsychotic medication used for maintenance/long-term treatment of schizophrenia or other psychotic disorders. |
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V1268 | Pergolide Mesylate (LY127809) | 66104-23-2 | Pergolide Mesylate (Permax; Pergotoliderived; LY127809; LY-127809), the mesylate salt of Pergolide, is a novel and potent antiparkinsonian agent which acts as a dopaminergic agonist. |
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V2706 | Perphenazine | 58-39-9 | Perphenazine (also known as Perphenazin, Trilafon, Etaperazine) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. |
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V50934 | Perphenazine-d4 | 155593-75-2 | Perphenazine-d4 is the deuterium labeled Perphenazine. |
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V4441 | PF-06256142 | 1609583-14-3 | PF-06256142 is a novel, potent and selective orthosteric agonist of the D1 receptor with D1 EC50of 30 nM and D1 binding Kiof 12 nM. |
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