Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Purity: ≥98%
Atipamezole (Antisedan, MPV-1248) is a synthetic α2 adrenergic receptor antagonist with a Ki of 1.6 nM. It has also been studied as a possible anti-Parkinsonian medication in humans. Atipamezole, an alpha2-adrenoceptor antagonist, was a strong inhibitor of aldosterone release (with a 10-1000 nM range). Alpha 2/alpha 1 selectivity ratio of 8526 was found for atipamezole in receptor binding studies [(3H]-clonidine and [3H]-prazosin displacement], whereas ratios of 27 and 40 were observed for idazoxan and yohimbine, respectively. In comparison to reference compounds, atipamezole exhibited an approximately 100-fold greater affinity for alpha 2-adrenoceptors.
Targets |
α2 adrenergic receptor
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ln Vitro |
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ln Vivo |
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Enzyme Assay |
Atipamezole Hcl(MPV1248 Hcl) exhibits high affinity and selectivity for the alpha 2-receptor as an antagonist of alpha-adrenoceptors.
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Animal Protocol |
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References |
Molecular Formula |
C14H16N2
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Molecular Weight |
212.29
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Exact Mass |
212.13
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Elemental Analysis |
C, 79.21; H, 7.60; N, 13.20
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CAS # |
104054-27-5
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Appearance |
Solid powder
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SMILES |
CCC1(CC2=CC=CC=C2C1)C3=CN=CN3
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InChi Key |
HSWPZIDYAHLZDD-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16)
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Chemical Name |
5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole
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Synonyms |
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HS Tariff Code |
2934.99.03.00
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 4.7105 mL | 23.5527 mL | 47.1054 mL | |
5 mM | 0.9421 mL | 4.7105 mL | 9.4211 mL | |
10 mM | 0.4711 mL | 2.3553 mL | 4.7105 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT01435213 | Completed | Drug: Atipamezole Drug: Atomoxetine |
Healthy | University of Turku | September 2011 | Phase 1 |