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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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5g |
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10g |
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Other Sizes |
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Purity: ≥98%
Bambuterol HCl (Bambec; Oxeol; KWD-2183l; UNII-Y1850G1OVC), the hydrochloride salt of Bambuterol which is a prodrug of terbutaline, is a potent and long acting beta-adrenoceptor agonist (LABA) that was approved (outside the US) for use in the treatment of asthma. Bambuterol functions as a bronchodilator, extending the duration of suxamethonium-induced neuromuscular blockade by inhibiting plasma BChE (cholinesterase) during metabolism.
Targets |
beta-adrenoceptor
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ln Vitro |
Bambuterol ((±)-Bambuterol hydrochloride; KWD-2183 hydrochloride) should not be taken by pregnant women or those with severe liver impairment. Renal impairment sufferers can use it, but dose modifications are required. Similar to salbutamol, bambuterol can cause similar adverse effects, such as headache, dizziness, tremor, nausea, and exhaustion.
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References |
Molecular Formula |
C18H30CLN3O5
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Molecular Weight |
403.90
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Exact Mass |
403.19
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Elemental Analysis |
C, 40.74; H, 3.65; Br, 18.07; N, 15.84; O, 21.71
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CAS # |
81732-46-9
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Related CAS # |
Bambuterol-d9 hydrochloride; 1794810-59-5; Bambuterol; 81732-65-2
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Appearance |
Solid powder
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SMILES |
CC(C)(C)NCC(C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O.Cl
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InChi Key |
LBARATORRVNNQM-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C18H29N3O5.ClH/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7;/h8-10,15,19,22H,11H2,1-7H3;1H
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Chemical Name |
[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate;hydrochloride
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 3 mg/mL (7.43 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 3 mg/mL (7.43 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 3 mg/mL (7.43 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 50 mg/mL (123.79 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.4759 mL | 12.3793 mL | 24.7586 mL | |
5 mM | 0.4952 mL | 2.4759 mL | 4.9517 mL | |
10 mM | 0.2476 mL | 1.2379 mL | 2.4759 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT01796730 | Completed | Drug: bambuterol Drug: Placebo |
COPD | The First Affiliated Hospital of Guangzhou Medical University |
February 2013 | Phase 4 |