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    6H05 TFA
    6H05 TFA

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1571
    CAS #: 2061344-88-3Purity ≥98%

    Description: 6H05 TFA, the trifluoroacetic acd salt of 6H05, is a potent, selective and allosteric inhibitorof the common oncogenic mutant K-Ras (G12C). 6H05 allosterically modifies and inhibits the oncogenic G12C mutant of highly homologous protein H-Ras, not affecting the wild-type K-Ras. Although it’s necessary to perform continued chemical optimization of 6H05 to be assessed in vivo, preliminary evaluation of 6H05 in lung cancer cell lines suggests that 6H05 shows allele-specific impairment of K-Ras function. 

    References: Nature. 2013 Nov 28;503(7477):548-51; Med Res Rev. 2014 Nov;34(6):1242-85.

    Related CAS: 2061344-88-3 (6H05 TFA salt); 1469337-95-8 (free base)

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    • 香港大学
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    Molecular Weight (MW)590.14
    FormulaC20H30ClN3O2S3.CF3COOH
    CAS No.1469337-95-8
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (169.5 mM)
    Water: 100 mg/mL (169.5 mM)
    Ethanol: 100 mg/mL (169.5 mM)
    Other info

    Chemical Name: 1-[2-[(4-Chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-4-piperidinecarboxamide 2,2,2-trifluoroacetate

    InChi Key: YNMYIJSFFJXIRV-UHFFFAOYSA-N

    InChi Code: InChI=1S/C20H30ClN3O2S3.C2HF3O2/c1-23(2)12-14-29-28-13-9-22-20(26)16-7-10-24(11-8-16)19(25)15-27-18-5-3-17(21)4-6-18;3-2(4,5)1(6)7/h3-6,16H,7-15H2,1-2H3,(H,22,26);(H,6,7)

    SMILES Code: O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C.O=C(O)C(F)(F)F           

    Synonyms

    6 H 05 TFA; 6 H 05 TFA salt; 6H05 TFA; 6H05 TFA salt; 6-H-05 TFA; 6-H-05 TFA salt; K-Ras(G12C) inhibitor 6H05


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    In Vitro

    In vitro activity: 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras. Furthermore, 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors.


    Cell Assay: Although it’s necessary to perform continued chemical optimization of 6H05 to be assessed in vivo, preliminary evaluation of 6H05 in lung cancer cell lines suggests that 6H05 shows allele-specific impairment of K-Ras function[1]. There are questions still need to be illustrated that the selectivity and efficiency of 6H05 in vivo, as well as its effects on the subcellular localization of other farnesylated GTPases should be assessed further.

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    References

    Nature. 2013 Nov 28;503(7477):548-51; Med Res Rev. 2014 Nov;34(6):1242-85.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    K-Ras(G12C) inhibitor 12

    Inhibitor sensitivity, K-Ras GTP levels and K-Ras dependency of lung cancer cell lines.Nature. 2013 Nov 28;503(7477):548-51.
     

    K-Ras(G12C) inhibitor 12

    Tethering compounds selectively bind to oncogenic K-Ras(G12C). Nature. 2013 Nov 28;503(7477):548-51.



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