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    Ciprofibrate
    Ciprofibrate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0833
    CAS #: 52214-84-3Purity ≥98%

    Description: Ciprofibrate (BRN-1984981; CCRIS 173; CCRIS173; Win-35833; BRN 1984981; BRN1984981;CCRIS-173) is a potent and selective agonist of PPAR/peroxisome proliferator-activated receptor agonist with antilipidemic activity. It was developed and approved in 1985 as a lipid-lowering agent. Ciprofibrate acts by activating PPARα with an EC50 value of 20 µM and only marginally affects PPARγ (EC50 = >300 µM). It has been shown to lower adipose tissue weight and reduce plasma insulin concentrations in obese rats and has been used clinically in the treatment of dyslipidemia. 

    References: J Biol Chem. 2000 Jun 2;275(22):16638-42.

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    Molecular Weight (MW)289.15
    FormulaC13H14Cl2O3
    CAS No.52214-84-3
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 58 mg/mL (200.6 mM)
    Water: <1 mg/mL
    Ethanol: 58 mg/mL (200.6 mM)
    Other info

    Chemical Name: 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoic acid

    InChi Key: KPSRODZRAIWAKH-UHFFFAOYSA-N

    InChi Code: InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)

    SMILES Code: CC(C)(OC1=CC=C(C2C(Cl)(Cl)C2)C=C1)C(O)=O           

    Synonyms BRN-1984981; CCRIS 173; CCRIS173; Win-35833; BRN 1984981; BRN1984981;CCRIS-173; Ciprofibrate; WIN 35833; WIN35833 


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    Ciprofibrate


    Ciprofibrate decreases the plasma insulin response to glucose in obese Zucker rats. J Biol Chem. 2000 Jun 2;275(22):16638-42.
     

    Ciprofibrate


    PPAR α activators decrease serum insulin concentrations in older obese Zucker rats. J Biol Chem. 2000 Jun 2;275(22):16638-42.
     

    Ciprofibrate

    PPAR α activators increase CD36/FAT mRNA levels in liver, but not in adipose tissue of older obese Zucker rats. J Biol Chem. 2000 Jun 2;275(22):16638-42.


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