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    Irsogladine
    Irsogladine

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0796
    CAS #: 57381-26-7Purity ≥98%

    Description: Irsogladine (MN1695; MN 1695; Gaslon; MN-1695; Dicloguamine), a mucosal protective drug, is a novel and potent PDE4 inhibitor and muscarinic acetylcholine receptor binder with anti-ulceric activity. It is used as an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3%.

    References: J Surg Res. 1998 Jul 1;77(2):126-31; Pancreas. 2002 Nov;25(4):373-7.

    Related CAS #: 84504-69-8 (maleate); 57381-26-7 (free base);

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    Molecular Weight (MW)256.09
    FormulaC9H7Cl2N5
    CAS No.57381-26-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 2 mg/mL (7.8 mM)
    Water:<1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine 

    SMILES Code: NC1=NC(N)=NC(C2=CC(Cl)=CC=C2Cl)=N1

    SynonymsMN1695; MN 1695; Gaslon; MN-1695; Irsogladine maleate; 


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    In Vitro

    In vitro activity: Irsogladine up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy. Irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions 

    In VivoIrsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice.  
    Animal modelMice
    Formulation & Dosage300 and 500 mg/kg
    References

    J Surg Res. 1998 Jul 1;77(2):126-31; Pancreas. 2002 Nov;25(4):373-7; Life Sci. 2004 Aug 27;75(15):1833-42.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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