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    Dyphylline
    Dyphylline

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0793
    CAS #: 479-18-5Purity ≥98%

    Description: Dyphylline (also named as Diprophylline; Corphyllin; Lufyllin; Neothylline), a xanthine derivative with bronchodilator and vasodilator effects, is used in the treatment of respiratory disorders like cardiac dyspnea, asthma, and bronchitis. It acts as an adenosine receptor antagonist and PDE/phosphodiesterase inhibitor

    References: Ann Pharmacother. 1993 Jun;27(6):792-3.

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    Molecular Weight (MW)254.24
    FormulaC10H14N4O4
    CAS No.479-18-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 51 mg/mL (200.6 mM)
    Water:<1 mg/mL
    Ethanol: 51 mg/mL (200.6 mM)
    Solubility (In vivo)

    Chemical Name: 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione

    InChi Key: KSCFJBIXMNOVSH-UHFFFAOYSA-N

    InChi Code: InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3

    SMILES Code: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O

    SynonymsDiprophylline; Dyphylline; Lufyllin; Corphyllin; Neothylline


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    In Vitro

    In vitro activity: Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. Dyphylline is a phosphodiesterase inhibitor used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It also acts as an adenosine receptor antagonist. Dyphilline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles

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    References

    [1]. Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21.

    [2]. Iancu L, et al. Trials with xanthine derivatives in systemic treatment of psoriasis. Dermatologica. 1979;159(1):55-61.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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