| Size | Price | Stock | Qty |
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| 500mg |
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Purity: ≥98%
Dyphylline (also named as Diprophylline; Corphyllin; Lufyllin; Neothylline), a xanthine derivative with bronchodilator and vasodilator effects, is used in the treatment of respiratory disorders like cardiac dyspnea, asthma, and bronchitis. It acts as an adenosine receptor antagonist and PDE/phosphodiesterase inhibitor
| ln Vitro |
The xanthine derivative diprophylline, also marketed under the trade names Dilor and Lufyllin, has bronchodilator and vasodilator properties. Respiratory conditions such as bronchitis, heart dyspnea, and asthma are treated with it. It functions as a phosphodiesterase inhibitor and antagonist of adenosine receptors.
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| ln Vivo |
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| References |
[1]. Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21.
[2]. Yosry El-said, et al. In-vitro evaluation of sustained-release dyphylline tablets. Drug Development and Industrial Pharmacy. Volume 17, 1991 - Issue 2 |
| Molecular Formula |
C10H14N4O4
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| Molecular Weight |
254.24
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| CAS # |
479-18-5
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| Related CAS # |
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| SMILES |
O=C(N1C)N(C)C2=C(N(CC(O)CO)C=N2)C1=O
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| Synonyms |
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9333 mL | 19.6665 mL | 39.3329 mL | |
| 5 mM | 0.7867 mL | 3.9333 mL | 7.8666 mL | |
| 10 mM | 0.3933 mL | 1.9666 mL | 3.9333 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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