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Description: Dyphylline (also named as Diprophylline; Corphyllin; Lufyllin; Neothylline), a xanthine derivative with bronchodilator and vasodilator effects, is used in the treatment of respiratory disorders like cardiac dyspnea, asthma, and bronchitis. It acts as an adenosine receptor antagonist and PDE/phosphodiesterase inhibitor
References: Ann Pharmacother. 1993 Jun;27(6):792-3.
Chemical Name: 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione
InChi Key: KSCFJBIXMNOVSH-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3
SMILES Code: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. Dyphylline is a phosphodiesterase inhibitor used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It also acts as an adenosine receptor antagonist. Dyphilline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles
[1]. Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21.
[2]. Iancu L, et al. Trials with xanthine derivatives in systemic treatment of psoriasis. Dermatologica. 1979;159(1):55-61.
Purity ≥ 98%
NMR