Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago. One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on.The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0823 | Naringin | 10236-47-2 | Naringin (also known as Naringoside; AI319008;Aurantiin; AI3-19008), a flavanone-7-O-glycoside, is a novel, potent,natural flavanone glycoside found in citrus fruits (e. |
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V4600 | Orteronel (racemic) | 426219-18-3 | Orteronel racemate, the mixture of S-enantiomer and R-enantiomer of Orteronel (aslo known as TAK-700) which is a novel, potent and highly selective, orally bioavailable non-steroidal androgen synthesis inhibitor of human 17,20-lyase inhibitor with IC50 of 38 nM, it exhibits >1000-fold selectivity over other CYPs (e. |
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V0818 | Ozagrel | 82571-53-7 | Ozagrel (OKY046;KCT-0809;OKY046;Cataclot;KCT0809;Xanbo),an antiplatelet agent, is a potent and selective inhibitor of thromboxane A2 (TXA2 synthetase (IC50 = 11 nM) with antiplatelet activity. |
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V0817 | Ozagrel HCl (OKY046 HCl; KCT0809; Cataclot) | 78712-43-3 | Ozagrel HCl(OKY-046 HCl;KCT 0809;Cataclot; Xanbo;OKY046 HCl), the hydrochloride salt of the antiplatelet drug Ozagrel, is a selective inhibitor of thromboxane A(2) (TXA(2)) synthetase (IC50 = 11 nM) with potential use for for the improving postoperative cerebrovascular contraction and accompanying cerebral ischaemia. |
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V0816 | PF-4981517 | 1390637-82-7 | PF-4981517 (also named as PF 04981517; PF04981517,CYP-3cide,PF 4981517;PF4981517) is a specific andtime-dependent inactivator of human CYP3A4(P450) with IC50 of 0.03 μM, it exhibits >500-fold selectivity for inhibiting CYP3A4 over CYP3A5 and CYP3A7 and a time-dependent inactivation of human CYP3A4. |
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V0820 | Pioglitazone HCl | 112529-15-4 | Pioglitazone HCl (also known as Actos;U-72107A;AD-4833; AD4833, U-72107E), the hydrochloride salt of Pioglitazone which is approved and thiazolidinedione-based anti-diabetic drug, is a selective PPARϒ agonist with hypoglycemic activity. |
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V0809 | Piperine | 94-62-2 | Piperine (1-Piperoylpiperidine;Bioperine; 1-Piperoyl piperidine),a natural alkaloid found inPiper nigrum L,is an alkaloid accounting for the pungency of black pepper and long pepper, which has been used in some forms of traditional medicine and as an insecticide. |
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V0822 | Sodium Danshensu | 67920-52-9 | Sodium Danshensu (Danshensu Sodium), the sodium saltof danshensu, is a novel, potent,naturally occuring phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza with various biological activity (e. |
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V3877 | Stiripentol (BCX2600) | 49763-96-4 | Stiripentol (formerly known as BCX-2600; BCX2600;STP; trade name:Diacomit) is an FDA-approved anticonvulsant drug that inhibits the activity of several cytochromes P450 (P450s). |
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V0819 | TAK-700/Orteronel (s-isomer) | 566939-85-3 | Orterone (aslo known as TAK-700; TAK 700;TAK700) is an orally bioavailable non-steroidal androgen synthesis inhibitor of human 17,20-lyase inhibitor with potential anticancer activity. |
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V0802 | Voriconazole | 137234-62-9 | Voriconazole (UK-109496; UK109496; trade name Vfend) is a 2nd-generation and potent triazole-based antifungal drug used for treating a variety of fungal infections. |
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