Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4175 | Bay 60-7550 | 439083-90-6 | BAY-60-7550 (BAY-607550; BAY607550) is a novel, potent and selective PDE2 inhibitor with the potential to be used for the treatment of anxiety disorders. |
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V4193 | BAY 73-6691 | 794568-92-6 | BAY 73-6691 [(R)-BAY 73-6691] is a novel, potent, selective, and brain penetrantPDE9A(Phosphodiesterase 9) inhibitor. |
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V4194 | BAY 73-6691 racemate | 794568-90-4 | BAY 73-6691 racemate is a novel, potent, selective, and brain penetrantPDE9A(Phosphodiesterase 9) inhibitor. |
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V79907 | BAY-7081 | BAY-7081 is a potent, selective, orally bioactive, soluble cyanopyridinyl PDE9A inhibitor (antagonist) with IC50 of 15 nM. | |
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V3770 | BI-409306 | 1189767-28-9 | BI 409306 (SUB 166499) isa novel potent, selective and oral phosphodiesterase 9A (PDE9A)inhibitor. |
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V72079 | Braylin | 6054-10-0 | Braylin, a coumarin, is a potent phosphodiesterase-4 (PDE4) inhibitor and is involved in anti-inflammation and immunomodulation, making it a potential target for studying immuno-inflammatory diseases. |
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V72024 | BRD9500 | 1630760-75-6 | BRD9500 is a potent, orally bioactive phosphodiesterase 3 (PDE3) inhibitor (antagonist) with IC50s of 10 and 27 nM for PDE3A and PDE3B, respectively. |
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V4092 | BRL-50481 | 433695-36-4 | BRL-50481 is a novel, potent and selective inhibitor ofphosphodiesterase 7(PDE7) withIC50s of 0.15, 12.1, 62 and 490 μM forPDE7A,PDE7B,PDE4andPDE3, respectively. |
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V3992 | BW-A78U | 101155-02-6 | BW-A 78U is a novel and potent PDE4 (phosphodiesterase 4)inhibitor with anIC50of 3 μM. |
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V77168 | CALP1 TFA | CALP1 TFA is a calmodulin (CaM) agonist (Kd 88 µM) that binds to the CaM EF-hand/Ca2+ binding site. | |
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V72008 | CD00509 | 27430-18-8 | CD00509 is a Tdp1 inhibitor (antagonist) with IC50 of 0.71 μM. |
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V18334 | Cilostamide (OPC3689) | 68550-75-4 | Cilostamide (OPC3689) is a potent and highly selective inhibitor of type III phosphodiesterase (PDE3) (IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively), it has antithrombotic and anti-intimal hyperplastic activity. |
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V72064 | cis-ent-Tadalafil (cis-ent-IC-351; Tadalafil, (6S,12aR)-) | 171596-28-4 | cis-ent-Tadalafil (Tadalafil EP Impurity C) is a potent PDE5 inhibitor (antagonist) with IC50 of 5 nM and has blood pressure lowering activity. |
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V5298 | CP-671305 | 445295-04-5 | CP671305 is a potent, orally bioavailable, selective phosphodiesterase-4-D inhibitor (antagonist) with high activity. |
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V72075 | Crisaborole-d4 (Crisaborole-d4; AN-2728-d4; PF-06930164-d4) | 2268785-42-6 | Crisaborole-d4 is the deuterated form of Crisaborole. |
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V72014 | Cudetaxestat (BLD-0409) | 1782070-21-6 | Cudetaxestat (BLD-0409) is a potent, orally bioactive autotaxin inhibitor. |
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V19061 | D159687 | 1155877-97-6 | D159687 is a selective PDE4D inhibitor. |
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V72017 | Deltasonamide 2 hydrochloride | 2448341-55-5 | Deltasonamide 2 HCl is a competitive, high-affinity inhibitor of PDEδ with Kd of ~385 pM. |
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V79157 | Dipyridamole-d16 (Dipyridamole-d16) | Dipyridamole-d16 is the deuterated form of Dipyridamole. | |
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V72033 | Dipyridamole-d20 (Dipyridamole d20) | 1189983-52-5 | Dipyridamole-d20 is the deuterated form of Dipyridamole. |
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