Drug metabolites are created when a drug is metabolized into a different form that still has therapeutic effects. Active metabolites can be produced by drug metabolism redox reactions like heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations. In some rare circumstances, conjugation reactions can also produce an active metabolite.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V72166 | 1-Aminohydantoin hydrochloride | 2827-56-7 | 1-Aminohydantoin HCl is the major metabolite of nitrofurantoin in animal tissues and could be utilized as an indicator for the determination of veterinary drug residues in meat, milk, etc. |
|
V72154 | 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine | 89576-29-4 | 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine is the main degradation product of deltamethrin metabolized by prokaryotic protein (CYP6A14 and CYP6N6) complexes in vitro. |
|
V72268 | 1-Oxo Ibuprofen (Ibuprofen EP impurity J) | 65813-55-0 | 1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in Ibuprofen formulations. |
|
V72251 | 10,11-Dihydrocarbamazepine | 3564-73-6 | 10,11-Dihydrocarbamazepine is the bioactive metabolite of Oxcarbazepine. |
|
V72254 | 12-Hydroxynevirapine (12-hydroxyvirapine; 12-hydroxy-NVP; 12-OH-NVP) | 133627-24-4 | 12-Hydroxyvirapine (12-hydroxy-NVP; 12-OH-NVP) is the major oxidative metabolite of nevirapine. |
|
V9224 | 16alpha-Hydroxyprednisolone | 13951-70-7 | 16α-Hydroxyprednisolone is a metabolite generated by the CYP3A enzyme in the 22(R) epimer configuration of the glucocorticoid budesonide. |
|
V79595 | 16α-Hydroxyprednisolone-d3 (OH-PRED-d3) | 16α-Hydroxyprednisolone-d3 is the deuterated form of 16α-Hydroxyprednisolone. | |
|
V72197 | 18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-hydrogen sulfate) | 10251-38-4 | 18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent inhibitor of type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) in rat kidney microsomes The IC50 is 0.10 µM. |
|
V72282 | 2′,2′-Difluorodeoxyuridine (dFdU; 2',2'-Difluoro-2'-deoxyuridine) | 114248-23-6 | 2′,2′-Difluorodeoxyuridine (dFdU) is the major metabolite of Gemcitabine . |
|
V72252 | 2-Aminoflubendazole (Flubendazole EP Impurity B) | 82050-13-3 | 2-Aminoflubendazole is a metabolite of benzimidazole active molecules. |
|
V72264 | 2-NP-AHD | 623145-57-3 | 2-NP-AHD is a 2-nitrophenyl analogue of AHD, a metabolite of nitrofuran antibiotics, which could be utilized as an indicator of illegal use of nitrofuran-based active molecules. |
|
V72137 | 2-NP-AMOZ | 183193-59-1 | 2-NP-AMOZ is a 2-nitrophenyl analogue of the antibiotic Furaltadone metabolite AMOZ and may be utilized to detect protein-bound AMOZ. |
|
V72144 | 2-Phenyl-2-(2-pyridyl)acetonitrile (α-Phenyl-2-pyridineacetonitrile) | 5005-36-7 | 2-Phenyl-2-(2-pyridyl)acetonitrile is the major metabolite of SC 15396 partially metabolized by rat liver homogenate supernatant. |
|
V72285 | 2-Propyl-2-pentenoic acid | 60218-41-9 | 2-Propyl-2-pentenoic acid is a metabolite of Valproic acid. |
|
V72279 | 20-Carboxy-Leukotriene B4 (20-Carboxyleukotriene B4; 20-COOH LTB4) | 80434-82-8 | 20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4). |
|
V72190 | 28-Epirapamycin | 253431-35-5 | 28-Epirapamycin is an impurity of Rapamycin. |
|
V29383 | 2R,4R-Sacubitril | 766480-48-2 | 2R,4R-Sacubitril is an impurity of Sacubitril (AHU377), which is an FDA approved medication acting as a NEP (neutral endopeptidase 24.11)inhibitor and used as acomponent of the heart failure medicine LCZ696. |
|
V29404 | 2R,4S-Sacubitril | 761373-05-1 | 2R,4S-Sacubitril is an impurity of Sacubitril (AHU-377; AHU377), which is an FDA approved medication used in combination with valsartan (trade name Entrosto for the combo/cocktail)for the treatment of heart failure. |
|
V72296 | 2S,4R-Sacubitril (Sacubitril Valsartan impurity 16) | 2307668-79-5 | 2S,4R-Sacubitril is an impurity of Sacubitri. |
|
V72135 | 3'-Hydroxy Repaglinide-d5 | 1352792-15-4 | 3'-Hydroxy Repaglinide-d5 is the deuterium labelled form of 3'-Hydroxy Repaglinide. |
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