Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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Other Sizes |
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Purity: ≥98%
Rufinamide (also known as CGP-33101; E-2080; RUF-331; BANZEL; Inovelon) is a voltage-gated sodium channel blocker approved as an antiepilepic agent for seizure treatment. It is a board spectrum anticonvulsant that is used in combination with other medication and therapy to treat Lennox–Gastaut syndrome and various other seizure disorders. Rufinamide has efficacy for partial seizures. Rufinamide prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons.
ln Vitro |
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ln Vivo |
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Animal Protocol |
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References |
Int J Clin Pract.2006Nov;60(11):1497-501;J Vet Pharmacol Ther.2012 Dec;35(6):529-33
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Molecular Formula |
C10H8F2N4O
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Molecular Weight |
238.19
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CAS # |
106308-44-5
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SMILES |
O=C(C1=CN(CC2=C(F)C=CC=C2F)N=N1)N
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InChi Key |
POGQSBRIGCQNEG-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)
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Chemical Name |
1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
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Synonyms |
E-2080; RUF-331; E2080; CGP-33101; RUF331; CGP 33101; E 2080; RUF 331; CGP33101; Trade names: BANZEL; Inovelon.
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 4.1983 mL | 20.9916 mL | 41.9833 mL | |
5 mM | 0.8397 mL | 4.1983 mL | 8.3967 mL | |
10 mM | 0.4198 mL | 2.0992 mL | 4.1983 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.