Size | Price | Stock | Qty |
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100mg |
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500mg |
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1g |
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2g |
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5g |
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10g |
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Other Sizes |
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Purity: ≥98%
Tolperisone HCl (AV650; AV-650; N553; Midocalm; Muscalm; Mydocalm), the hydrochloride salt of tolperisone, is an ion channel blocker and centrally-acting muscle relaxant. It was approved for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia. Tolperisone reduces sodium and potassium permeability in the node of Ranvier of frogs, blocks calcium currents in snail neurons and inhibits current through heterologously expressed Nav1.6 channels. Tolperisone hydrochloride represents an effective and safe treatment of painful reflex muscle spasm without the typical side effects of centrally active muscle relaxants.
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ln Vivo |
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Animal Protocol |
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References |
Eur J Pharmacol.2006 May 24;538(1-3):5-14;Pain.1996 Oct;67(2-3):417-25.
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Molecular Formula |
C16H23NO.HCL
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Molecular Weight |
281.82
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CAS # |
3644-61-9
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Related CAS # |
Tolperisone-d10 hydrochloride;1185160-65-9
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SMILES |
Cl[H].O=C(C1C([H])=C([H])C(C([H])([H])[H])=C([H])C=1[H])C([H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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InChi Key |
ZBUVYROEHQQAKL-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H
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Chemical Name |
2-Methyl-3-piperidino-1-p-tolylpropan-1-one hydrochloride
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.5484 mL | 17.7418 mL | 35.4836 mL | |
5 mM | 0.7097 mL | 3.5484 mL | 7.0967 mL | |
10 mM | 0.3548 mL | 1.7742 mL | 3.5484 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.