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    Tolperisone HCl (AV 650)
    Tolperisone HCl (AV 650)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1658
    CAS #: 3644-61-9Purity ≥98%

    Description: Tolperisone HCl (AV650; AV-650; N553; Midocalm; Muscalm; Mydocalm), the hydrochloride salt of tolperisone, is an ion channel blocker and centrally-acting muscle relaxant. It was approved for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia. Tolperisone reduces sodium and potassium permeability in the node of Ranvier of frogs, blocks calcium currents in snail neurons and inhibits current through heterologously expressed Nav1.6 channels. Tolperisone hydrochloride represents an effective and safe treatment of painful reflex muscle spasm without the typical side effects of centrally active muscle relaxants.

    References: Eur J Pharmacol. 2006 May 24;538(1-3):5-14; Pain. 1996 Oct;67(2-3):417-25.

    Related CAS #: 728-88-1 (free base)   3644-61-9 (HCl)

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    Molecular Weight (MW)281.82 
    FormulaC16H23NO.HCl 
    CAS No.3644-61-9 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 56 mg/mL (198.7 mM) 
    Water: 56 mg/mL (198.7 mM)
    Ethanol: 56 mg/mL (198.7 mM) 
    Other info

    Chemical Name: 2-Methyl-3-piperidino-1-p-tolylpropan-1-one hydrochloride

    InChi Key: ZBUVYROEHQQAKL-UHFFFAOYSA-N

    InChi Code: InChI=1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H

    SMILES Code: O=C(C1=CC=C(C)C=C1)C(C)CN2CCCCC2.[H]Cl           

    Synonyms

    Tolperisone HCl; Tolperisone hydrochloride; AV 650; N-553; AV-650; N553; AV650; N553; Midocalm; Muscalm; Mydocalm.


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    In Vitro

    In vitro activity: Tolperisone reduces sodium and potassium permeability in the node of Ranvier of frogs, blocks calcium currents in snail neurons and inhibits current through heterologously expressed Nav1.6 channels. Tolperisone hydrochloride represents an effective and safe treatment of painful reflex muscle spasm without the typical side effects of centrally active muscle relaxants.

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    Formulation & Dosage
    References

    Eur J Pharmacol. 2006 May 24;538(1-3):5-14; Pain. 1996 Oct;67(2-3):417-25. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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