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Description: Mexiletine HCl (KO1173), belongs to Class IB anti-arrhythmic group of medications used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness, is a non-selective voltage-gated sodium channel blocker that inhibits sodium channels to reduce the inward sodium current. Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Mexiletine, inhibits the inward sodium current required for the initiation and conduction of impulses, thus reducing the rate of rise of the action potential. It achieves this reduced sodium current by inhibiting sodium channels.
References: Curr Med Chem. 2015;22(11):1400-13; Curr Pain Headache Rep. 2010 Apr;14(2):145-50.
Related CAS #: 31828-71-4 (free) 5370-01-4 (HCl)
Chemical Name: 1-(2,6-dimethylphenoxy)propan-2-amine hydrochloride
InChi Key: NFEIBWMZVIVJLQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
SMILES Code: CC(N)COC1=C(C)C=CC=C1C.[H]Cl
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Mexiletine, inhibits the inward sodium current required for the initiation and conduction of impulses, thus reducing the rate of rise of the action potential. It achieves this reduced sodium current by inhibiting sodium channels. Mexiletine decreases the effective refractory period (ERP) in Purkinje fibers in the heart. The decrease in ERP is of lesser magnitude than the decrease in action potential duration (APD), which results in an increase in the ERP/APD ratio. It does not significantly affect resting membrane potential or sinus node automaticity, left ventricular function, systolic arterial blood pressure, atrioventricular (AV) conduction velocity, or QRS or QT intervals
Curr Med Chem. 2015;22(11):1400-13; Curr Pain Headache Rep. 2010 Apr;14(2):145-50.
Purity ≥98%
COA
MSDS