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Description: Mexiletine HCl (Mexitil, Mexiletene, KO-1173, KO 1173; KO1173), the hydrochloride salt of Mexiletine, is an anti-arythmic drug of the Class IB group approved for use in the treatment of abnormal heart rhythms. It act as a non-selective voltage-gated sodium channel blocker that inhibits sodium channels. Mexiletine is also a local anesthetic which is structurally similar to lidocaine.
References: Curr Med Chem. 2015;22(11):1400-13; Curr Pain Headache Rep. 2010 Apr;14(2):145-50.
Related CAS #: 31828-71-4 (free) 5370-01-4 (HCl)
Product Catalog 2022
Guide to Product Handling
Chemical Name: 1-(2,6-dimethylphenoxy)propan-2-amine hydrochloride
InChi Key: NFEIBWMZVIVJLQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
SMILES Code: CC(N)COC1=C(C)C=CC=C1C.[H]Cl
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Mexiletine, inhibits the inward sodium current required for the initiation and conduction of impulses, thus reducing the rate of rise of the action potential. It achieves this reduced sodium current by inhibiting sodium channels. Mexiletine decreases the effective refractory period (ERP) in Purkinje fibers in the heart. The decrease in ERP is of lesser magnitude than the decrease in action potential duration (APD), which results in an increase in the ERP/APD ratio. It does not significantly affect resting membrane potential or sinus node automaticity, left ventricular function, systolic arterial blood pressure, atrioventricular (AV) conduction velocity, or QRS or QT intervals
Curr Med Chem. 2015;22(11):1400-13; Curr Pain Headache Rep. 2010 Apr;14(2):145-50.
Purity ≥98%
COA
MSDS