Sodium channels are membrane proteins that function as ion channels and transport sodium ions (Na+) across the plasma membrane of cells. They are divided into two categories based on what opens the channel for these ions: voltage changes (for voltage-gated, voltage-sensitive, or voltage-dependent sodium channels, also known as VGSCs or Nav channels), or ligand bindings (for ligand-gated sodium channels). The rising phase of action potentials is caused by sodium channels in excitable cells like neurons, myocytes, and some varieties of glia. There are three different states of voltage-gated Na+ channels: deactivated (closed), activated (open), and inactivated (closed). Instead of a change in membrane potential, ligand-gated sodium channels are activated by the binding of a ligand.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V1650 | Cilnidipine (FRC8653) | 132203-70-4 | Cilnidipine (formerly also known as FRC-8653; FRC8653;Atelec; Cinalong; Siscard)is a novel, potent and unique dual L-type and N-type calcium channel blocker (CCB) that was approved as an anti-hypertensive drug in 1995 for high blood pressure treatment. |
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V73720 | Cofirasersen (ION-827359) | 2247669-96-9 | Cofirasersen is an antisense oligonucleotide that reduces ENaC expression in the lungs. |
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V78845 | Cofirasersen sodium (ION-827359 sodium) | Cofirasersen sodium is an antisense oligonucleotide that reduces ENaC expression in the lungs. | |
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V2531 | CRMP2-Ubc9-NaV1.7 inhibitor 194 | 2241651-99-8 | Desription: CRMP2-Ubc9-NaV1.7 inhibitor 194 can prevent the SUMOylation of the NaV1.7-interacting protein CRMP2 and reduce NaV1.7 surface expression as well as current density. |
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V78886 | Crotamine | Crotamine is a Na+ channel modulator. | |
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V73704 | Cyfluthrin | 68359-37-5 | Cyfluthrin is a type II pyrethroid that has activity against a variety of insects. |
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V79031 | Dc1a | Dc1a effectively promotes the opening of the B.germanica Nav channel (BgNav1). | |
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V19772 | Dibucaine (Cinchocaine) | 85-79-0 | Dibucaine HCl (also known asCinchocaine),a sodium channel inhibitor,is one of the most potent and toxic of the long-acting local anesthetics. |
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V1667 | Dibucaine HCl (Cinchocaine) | 61-12-1 | Dibucaine HCl (also called Cincain; Nupercainal; Nupercaine; Sovcaine; Cinchocaine),the hydrochloride salt of dibucaine which is a sodium channel inhibitor,is one of the most potent and toxic of the long-acting local anesthetics. |
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V1648 | Digoxin (12β-Hydroxydigitoxin) | 20830-75-5 | Digoxin(12β-Hydroxydigitoxin; Dixina; HSDB-214; Novodigal; Lanoxin PG; SK-Digoxin; Cardiogoxin) is a sodium-potassium pump inhibitor and a cardiotonic glycoside that has been approved for use in the treatment of various heart conditions such as arrhythmia and heart failure. |
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V13770 | DPI-201-106 | 97730-95-5 | DPI-201-106 [(±)-SDZ-201 106] is a novel and potent inhibitor of the TTX-resistant h1 Na channelwhich is cardioselective. |
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V73662 | DS-1971a | 1450595-86-4 | DS-1971a is a specific, orally bioactive NaV1.7 inhibitor (antagonist) with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. |
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V73683 | DS43260857 | 1612158-07-2 | DS43260857 is an effective NaV1.7 inhibitor (antagonist) with high inhibitory effect on NaV1.7 in both humans and mice. |
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V20281 | DSP-2230 | 1233231-30-5 | DSP-2230 is a selective Nav1.7/Nav1.8 channel blocker. |
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V2846 | Eleclazine HCl | 1448754-43-5 | Eleclazine hydrochloride (also known as GS-6615) is a novel late Na+ current inhibitor with IC50 value of 0.7 uM. |
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V8989 | Eslicarbazepine acetate | 236395-14-5 | Eslicarbazepine acetate (ESL; Aptiom; Zebinix) is avoltage-gated sodium channel blocker and a β-Secretase inhibitor used as anantiepileptic/anti-convulsant drug. |
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V3242 | ETH2120 | 81686-22-8 | ETH2120 (also known as Sodium ionophore III) is aNa+ionophore that is suitable for the assay of sodium activity in blood, plasma, serum. |
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V73716 | Flecainide-d4 acetate (R-818-d4) | 1276197-21-7 | Flecainide-d4 (acetate) is the deuterated form of Flecainide acetate. |
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V4765 | Fosphenytoin Sodium (ACC-9653) | 92134-98-0 | Fosphenytoin sodium, the sodium salt form of fosphenytoin, is a prodrug ofphenytoin with similar anticonvulsant properties. |
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V73667 | GNE-0439 | 1241902-40-8 | GNE-0439 is a new selective inhibitor of Nav1.7 with IC50 of 0.34 uM and inhibits Nav1.5 with IC50 of 38.3 μM. |
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