Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73631 | Clobutinol | 14860-49-2 | Clobutinol is a compound that has antitussive effects. |
|
V73584 | Clobutinol hydrochloride | 1215-83-4 | Clobutinol HCl Clobutinol is a compound with antitussive effects. |
|
V4951 | Clofilium tosylate | 92953-10-1 | Clofilium tosylate, the tosylate salt of clofilium, is a novel and potent potassium/K+ channel blocker with the potential to be used as a cardiac depressant and anti-arrhythmic agent. |
|
V18559 | CLP-290 | 1181083-81-7 | CLP-290 is a novel and potent KCC2 modulator acting as a prodrug of CLP-257, and is highly selective for KCC2 over related Cl- transporters. |
|
V79006 | DAD | DAD is an ion channel blocker that blocks voltage-gated potassium channels and is a third-generation photoswitch that responds to visible light. | |
|
V78641 | DAD dichloride | DAD dichloride is an ion channel blocker (blocks voltage-gated potassium channels) and a third-generation photoswitch that responds to visible light. | |
|
V77108 | Dalazatide TFA (ShK-186 TFA) | Dalazatide (ShK-186) TFA is a specific peptide inhibitor of Kv1.3 potassium channel. | |
|
V77091 | Dendrotoxin K TFA | Dentrotoxin K TFA is a Kv1.1 channel blocker. | |
|
V73639 | Dendrotoxin-I (DTX-I) | 107950-33-4 | Dendrotoxin-I is a potent K+ channel blocker that targets the voltage-gated potassium channel subunits KV1.1 and KV1.2. |
|
V4676 | Diazoxide | 364-98-7 | Diazoxide (also known as Proglycem) is a potassium channel activator used to treat hyperinsulinism. |
|
V50907 | Dihydralazine | 484-23-1 | antihypertensive agent |
|
V73660 | Dihydroisopimaric acid | 5673-36-9 | Dihydroisopimaric acid activates BK channel alphabeta1 under whole-cell voltage clamping. |
|
V1671 | Dofetilide (UK 68789) | 115256-11-6 | Dofetilide (formerly UK-68789; UK68789;Dofetilidum;Tikosyn)is a potent and selective potassium channel (hERG) blocker approved for use as a Class III antiarrhythmic drug. |
|
V0087 | Doxapram (AHR-619, Dopram, Stimulex or Respiram) | 309-29-5 | Doxapram(AHR619, Dopram, Stimulex or Respiram) is a novel potent respiratory stimulant that acts by inhibiting the potassium channels such as TASK-1, TASK-3, TASK-1/TASK-3 with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
|
V10387 | Doxapram hydrochloride (AHR-619) | 7081-53-0 | Doxapramhydrochloride (AHR619)is a respiratory stimulant that can also inhibit TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
|
V73603 | DPO-1 | 43077-30-1 | DPO-1 is a potent inhibitor of the voltage-gated potassium channel Kv1.5 and a blocker of ultrafast delayed rectifier potassium currents. |
|
V1670 | Dronedarone HCl (SR33589) | 141625-93-6 | Dronedarone HCl (formerly SR-33589;D4689; W3083; D03914; S-7529; RL01735),the hydrochloride salt of dronedarone,is a non-iodinated amiodarone analog approved for the treatment for Atrial fibrillation (AF). |
|
V3382 | E4031 diHCl | 113559-13-0 | E-4031 diHCl (E4031 dihydrochloride) is a novel, potent and selective blocker of hERG K+ channels, which is also termed as a class III antiarrhythmic agent. |
|
V1680 | Esomeprazole sodium (S-Omeprazole sodium) | 161796-78-7 | Esomeprazole Sodium (formerly 18-sodium;H199;18 sodium;H-199;Nexium IV; S-Omeprazole sodium), the sodium salt of esomeprazole, is the S-isomer of omeprazole which is a potent PPI-proton pump inhibitor with an IC50 of 0.076 mg/kg. |
|
V3359 | F-1 | 2244775-31-1 | F-1 is a potent dual (bifunctional) inhibitor of ALK and ROS1, inhibiting ALK phosphorylation and downstream pathways. |
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