Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73615 | Antiarrhythmic agent-1 | 136081-07-7 | Antiarrhythmic agent-1 (Example I) is an antiarrhythmic agent and IKr potassium channel inhibitor (IC50<1 μM). |
|
V73607 | AP14145 hydrochloride | 2387505-59-9 | AP14145 HCl is a potent NAM (negative allosteric modulator) of KCa2 (SK) channels with IC50 of 1.1 μM for both KCa2.2 (SK2) and KCa2.3 (SK3) channels. |
|
V77250 | Apamin TFA (Apamin TFA) | Apamin TFA (Apamine TFA) is an 18-amino acid (AA) peptide neurotoxin found in melittin. | |
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V73590 | ASP2905 | 792184-90-8 | ASP2905 is a potent and specific potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. |
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V11905 | AUT1 | 1311136-84-1 | AUT1 is a Kv3 potassium channel modulator which increases whole currents mediated by human Kv3.1b and Kv3.2a channels, with a concomitant leftward shift in the voltage-dependence of activation, while having a less potent effect on hKv3.3 currents. |
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V79246 | Azimilide-d8 dihydrochloride (NE-10064-dd8 (dihydrochloride)) | Azimilide-d8 (di-HCl) is the deuterated form of Azimilide di-HCl. | |
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V1933 | BAPTA-AM | 126150-97-8 | BAPTA-AM is a selective, membrane-permeable andintracellularcalcium chelator. |
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V73648 | BDS-I | 207621-38-3 | BDS-I, also known as blood-lowering substances, is a marine toxin found in the sulcata anemone flower. |
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V73604 | BeKm-1 | 524962-01-4 | BeKm-1 is a HERG (human ethera-go-go-related gene) blocking compound. |
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V78365 | BeKm-1 TFA | BeKm-1 TFA is a potent and specific KV11.1 (hERG) channel blocker. | |
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V78491 | BmP02 | BmP02 is a selective Kv1.3 channel blocker and selective Kv4.2 modulator extracted from the venom of the Chinese scorpion (Buthus martensi Karsch). | |
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V3481 | BMS-191095 | 166095-21-2 | BMS-191095 is a novel and potent activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. |
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V73595 | Cesium chloride | 7647-17-8 | Cesium chloride is a potassium channel inhibitor. |
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V77154 | Charybdotoxin TFA | Charybdotoxin TFA is a 37-amino acid (AA) peptide that is a K+ channel blocker. | |
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V73646 | Chlorahololide C | 1007859-25-7 | Chlorahololide C is a lindane sesquiterpene dimer extracted from Chloranthus holostegius. |
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V73636 | Chlorahololide D | 943136-39-8 | Chlorahololide D is a potent and specific Potassium Channel blocker with IC50 of 2.7 μM. |
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V73596 | Chromanol 293B | 163163-23-3 | Chromanol 293B selectively blocks slow delayed rectifier potassium currents (IKs) with IC50 of 1-10 μM and is a weak inhibitor of KATP channels. |
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V73601 | Cibenzoline (Cifenline; Ro 22-7796) | 53267-01-9 | Cibenzoline is a potent KATP channel inhibitor that directly affects the pore-forming Kir6.2 subunit but not the SUR1 subunit. |
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V1681 | Ciclopirox ethanolamine (HOE 296) | 41621-49-2 | Ciclopirox ethanolamine (formerly HOE-296; HOE296; Ciclopirox olamine), the ethanolamine salt ofCiclopirox,is a novel, investigational, synthetic, potent and broad-spectrum antifungal agent working as an iron chelator and used as an antifungal agent for topical dermatologic treatment of superficial mycoses. |
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V73605 | Clamikalant sodium (HMR 1098) | 261717-22-0 | Clamikalant sodium (HMR 1098) is a non-selective and ATP-sensitive potassium (KATP) channel blocker. |
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