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    E4031
    E4031

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V3382
    CAS #: 113559-13-0 (2HCl salt); 113558-89-7 (free base)Purity ≥98%

    Description: E-4031 is a novel, potent and selective blocker of hERG K+ channels, which is also termed as a class III antiarrhythmic agent. It selectively blocks hERG potassium (K+) channels. E4031 inhibits the rapid delayed-rectifier K+ current (IKr) and reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents.

    References: Br J Pharmacol. 2012 Jan;165(2):467-78. 2014 Oct 5;740:263-70.   

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    E4031Name: E4031 HCl
    CAS#: 113559-13-0 (2HCl)
    Chemical Formula: C21H29Cl2N3O3S
    Exact Mass: 401.1773
    Molecular Weight: 474.44
    Elemental Analysis: C, 53.16; H, 6.16; Cl, 14.94; N, 8.86; O, 10.12; S, 6.76
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: E4031; E-4031; E 4031; E4031 2HCl; E4031 dihydrochloride
    Chemical Name: N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride
    InChi Key: ZQBNWMFBOSOOLX-UHFFFAOYSA-N
    InChi Code: InChI=1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H
    SMILES Code: CS(=O)(NC1=CC=C(C(C2CCN(CCC3=NC(C)=CC=C3)CC2)=O)C=C1)=O.[H]Cl.[H]Cl


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     E4031


    APD90, BVR and example of APs in hESC-CM.  2012 Jan;165(2):467-78.




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