Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73609 | Foslevcromakalim (QLS-101) | 1802655-72-6 | Foslevcromakalim (QLS-101) is an ATP-sensitive potassium channel opener. |
|
V21472 | GAL-021 | 1380341-99-0 | GAL-021 is a potent BKCa channel blocker. |
|
V73618 | Glibenclamide potassium (Glyburide potassium) | 52169-36-5 | Glibenclamide (Glyburide) potassium is the potassium salt form of Glibenclamide. |
|
V0229 | Gliclazide (S1702; Diamicron) | 21187-98-4 | Gliclazide (S-1702; trade names Diamicron among others),a sulfonylurea insulin secretagogue,is an approved medication forthe treatment of type 2 diabetes. |
|
V73600 | Gliclazide-d4 (Gliclazide d4) | 1185039-30-8 | Gliclazide-d4 is the deuterated form of Gliclazide. |
|
V1673 | Glimepiride (Glimperide; HOE-490) | 93479-97-1 | Glimepiride (HOE-490; HOE490; Amaryl;Glimepiridum;Amarel; Glimepirida; Roname), a third generation andmedium-to-long actingsulfonylurea compound, is a potent Kir6.2/SUR inhibitor with potential antidiabetic activity. |
|
V73655 | Glipizide-d11 (Glipizide d11) | 1189426-07-0 | Glipizide-d11 is the deuterium labelled form of Glipizide. |
|
V0218 | Gliquidone (AR-DF26) | 33342-05-1 | Gliquidone(also known as AR-DF 26; Glurenorm; Beglynor)is a potent ATP-sensitive K+ channel antagonist with potential anti0diabetic activity. |
|
V1678 | Glyburide (Glibenclamide) | 10238-21-8 | Glyburide (formerly HB419; HB420;Glibenclamide;Micronase; Diabeta; Maninil; Micronase; Neogluconin) is a selective blocker of vascular ATP-sensitive K+ channels (KATP) that has been approved as an antidiabetic sulfonylurea drug used for the treatment of type 2 diabetes. |
|
V73647 | GoSlo-SR-5-69 | 1363419-31-1 | GoSlo-SR-5-69 is an activator of conductivity Ca2+-activated K+ (BK) channels with EC50 of 251 nM. |
|
V79654 | GsAF-I | GsAF-I is a potent Nav and hERG1 channel blocker, with IC50s of 0.36, 0.6, and 1.28, 0.33, 1.2, 0.04 and 4.8 μM. | |
|
V79655 | GsAF-II | GsAF-II is a bioactive peptide toxin that blocks hERG1 subtype potassium channels in a voltage-dependent manner. | |
|
V3563 | GSK369796 Dihydrochloride | 1010411-21-8 | GSK369796 dihydrochloride is a novel, potent and effectiveantimalarialand inhibitshERG potassium ion channelrepolarization with anIC50of 7.5 μM. |
|
V60085 | Guan-fu base A | 1394-48-5 | Coranthrine A is an antiarrhythmic alkaloid extracted from Aconitum coreanum and is a potent, noncompetitive CYP2D6 artifact with a Ki of 1.20 μM against human liver microsomes (HLM) and against human recombinants ( rCYP2D6) has a Ki of 0.37 μM. |
|
V73650 | Guanfu base G | 78969-72-9 | Guanfu base G is an antiarrhythmic alkaloid extracted from Aconitum coreanum. |
|
V73598 | Guangxitoxin 1E | 1233152-82-3 | Guangxitoxin 1E is a potent and specific blocker of KV2.1 and KV2.2 channels. |
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V79750 | Hemitoxin | Hemitoxin is a scorpion venom peptide and a K+ channel blocker. | |
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V79767 | Heteropodatoxin-1 | Heteropodatoxin-1 (HpTx1) is a spider peptide toxin that is a Kv4.2 current inhibitor. | |
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V73613 | Heteropodatoxin-2 | 741730-12-1 | Heteropodatoxin-2 is a 30-amino acid (AA) peptide that is a heteropodoxin. |
|
V79816 | Hongotoxin-1 | Hongotoxin-1 is extracted from the venom of the scorpion Centruroideslimbatus and is an inhibitor (blocker/antagonist) of the potassium channel. |
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