Nicotinic acetylcholine receptors, or nAChRs, are proteins on neurons that signal when a chemical stimulus causes muscles to contract. On the presynaptic and postsynaptic sides of the neuromuscular junction, as well as in the plasma membranes of some neurons, they are cholinergic receptors that create ligand-gated ion channels. The most extensively researched ionotropic receptors are those for nicotinic acetylcholine. The neurotransmitter acetylcholine (ACh) binds to the nAChR, just like it does with the other type of acetylcholine receptor, the muscarinic acetylcholine receptor (mAChR). Nicotinic receptors can be opened by both acetylcholine and nicotine, hence the name "nicotinic," just as muscarinic receptors are so named because they are also activated by muscarine.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V20529 | Encenicline | 550999-75-2 | Encenicline (EVP-6124; MT-4666) is a novel partial agonist of α7 nicotinic acetylcholine receptor. |
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V70773 | Epiboxidine | 188895-96-7 | Epiboxidine is a potent and specific neural nAChR agonist/activator with Ki of 0.46 nM and 1.2 nM for rat and human α4β2 nAChR, respectively. |
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V70718 | Epiboxidine hydrochloride | 862909-67-9 | Epiboxidine HCl is a potent and specific neural nAChR agonist/activator with Ki of 0.46 nM and 1.2 nM for rat and human α4β2 nAChR, respectively. |
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V70738 | Ferulamide | 61012-31-5 | Ferulamide is a ferulic acid analogue extracted from Portulaca oleracea L. |
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V79433 | FITC-α-Bungarotoxin | FITC-α-Bungarotoxin is FITC-labeled α-Bungarotoxin . | |
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V70716 | Flupyradifurone | 951659-40-8 | Flupyradifurone is an nAChR agonist that interferes with signal transduction in the central nervous system/CNS of pests and could be utilized as an insecticide. |
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V70734 | ikB | 525596-66-1 | bPiDDB is a potent nAChR antagonist. |
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V80631 | LtIA-F | LtIA-F is a novel fluorescent analog of LtIA that provides a rich pharmacological tool for exploring the structure-activity relationship, distribution and ligand-binding domain of α3β2 nAChR isoforms. | |
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V70752 | Lupanine (D-Lupanine) | 550-90-3 | Lupanine (D-Lupanine) is a natural ketone analogue of Sparteine ((+)-Sparteine ) with ganglionic paralyzing activity. |
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V70733 | Lupanine hydrochloride (D-Lupanine hydrochloride) | 1025-39-4 | Lupanine (D-Lupanine) HCl is a natural ketone analogue of Sparteine ((+)-Sparteine ) and has ganglionic paralyzing activity. |
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V80731 | Mecamylamine hydrochloride-13C4,15N (Mecamylamine hydrochloride-13C4,15N) | Mecamylamine ( HCl)-13C4,15N is a 13C (carbon 13) and 15N (nitrogen 15) labelled Mecamylamine ( HCl). | |
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V1923 | Meclofenoxate (Centrophenoxine) HCl | 3685-84-5 | Meclofenoxate (also known as Centrophenoxine) HCl is a potent nootropic agent and an anti-aging drug used to treat the symptoms of senile dementia and Alzheimers disease, and also inhibits the activity of cholinephosphotransferase. |
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V70782 | Microgrewiapine A | 1420777-30-5 | Microgrewiapine A is an antagonist of nAChR. |
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V70708 | Myosmine | 532-12-7 | Myosmine is a specific tobacco alkaloid found in nuts and nut products that has low affinity for the a4b2 nicotinic acetylcholine receptor (nAChR) with a Ki of 3300 nM. |
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V70731 | Myosmine-d4 (Myosmine-d4) | 66148-17-2 | Myosmine-d4 is the deuterium labelled form of Myosmine. |
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V37652 | nAChR agonist 1 | 1394371-75-5 | nAChR agonist 1 is a novel, brain-permeable, and orally bioavailable positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptor (α7 nAChR). |
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V70724 | nAChR agonist CMPI hydrochloride | 2250025-94-4 | nAChR agonist CMPI HCl is a potent and specific PAM (positive allosteric modulator) of nAChR containing an α4:α4 subunit interface. |
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V70700 | nAChR-IN-1 hydrochloride | 849461-91-2 | nAChR-IN-1 ( HCl), a tetramethylpiperidinyl enanthate, is a selective inhibitor of the nicotinic acetylcholine receptor (nAChR) lacking the α5, α6, or β3 subunits. |
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V70725 | nAChRagonist 2 | 252870-46-5 | nAChR agonist 2 (compound 8) is a selective α4β2 nAChR (nicotinic acetylcholine receptor) agonist (Kd=26 nM). |
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V4407 | Nelonicline | 1026134-63-3 | Nelonicline (aslo known as ABT-126) is a novel, potent and selectiveneuronal nicotinicreceptor agonist. |
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