Nicotinic acetylcholine receptors, or nAChRs, are proteins on neurons that signal when a chemical stimulus causes muscles to contract. On the presynaptic and postsynaptic sides of the neuromuscular junction, as well as in the plasma membranes of some neurons, they are cholinergic receptors that create ligand-gated ion channels. The most extensively researched ionotropic receptors are those for nicotinic acetylcholine. The neurotransmitter acetylcholine (ACh) binds to the nAChR, just like it does with the other type of acetylcholine receptor, the muscarinic acetylcholine receptor (mAChR). Nicotinic receptors can be opened by both acetylcholine and nicotine, hence the name "nicotinic," just as muscarinic receptors are so named because they are also activated by muscarine.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V81790 | α-Conotoxin Vc1.1 TFA | α-Conotoxin Vc1.1 TFA is a disulfide peptide extracted from Conus victoriae and a selective nAChR antagonist. | |
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V70717 | α7 Nicotinic receptor agonist-1 | 220100-05-0 | α7 Nicotinic receptor agonist-1 (Preparation 5) is an α7 nAChR agonist. |
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V70756 | αA-Conotoxin OIVA (αA-OIVA) | 878027-87-3 | αA-Conotoxin OIVA (αA-OIVA) is a selective nAChR antagonist (inhibitor) with IC50 of 56 nM for mammalian fetal muscle nAChR. |
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V70728 | αA-Conotoxin PIVA | 171439-59-1 | αA-Conotoxin PIVA is a selective mouse muscle nAChR inhibitor, with IC50s of 2.3 nM and 22 nM for adult and fetal mouse muscle nAChR, respectively. |
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V73428 | αC-Conotoxin PrXA (αC-PrXA) | αC-Conotoxin PrXA is a paralytic peptide neurotoxin and competitive nAChR antagonist (inhibitor) with IC50 of 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal), respectively. | |
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V70739 | αO-Conotoxin GeXIVA | 2010167-25-4 | αO-Conotoxin GeXIVA is a potent α9α10 nAChR antagonist (inhibitor) with IC50 of 12 nM for rat α9α10. |
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V70769 | κ-Bungarotoxin (κ-Bgt) | 124511-67-7 | κ-Bungarotoxin (κ-Bgt) is a specific, slowly reversible antagonist of the α3β2 neuronal nicotinic acetylcholine receptor with IC50 of 2.30 nM. |
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