Nicotinic acetylcholine receptors, or nAChRs, are proteins on neurons that signal when a chemical stimulus causes muscles to contract. On the presynaptic and postsynaptic sides of the neuromuscular junction, as well as in the plasma membranes of some neurons, they are cholinergic receptors that create ligand-gated ion channels. The most extensively researched ionotropic receptors are those for nicotinic acetylcholine. The neurotransmitter acetylcholine (ACh) binds to the nAChR, just like it does with the other type of acetylcholine receptor, the muscarinic acetylcholine receptor (mAChR). Nicotinic receptors can be opened by both acetylcholine and nicotine, hence the name "nicotinic," just as muscarinic receptors are so named because they are also activated by muscarine.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70745 | Nelonicline citrate (ABT-126 citrate) | 1026136-84-4 | Nelonicline (ABT-126) citrate is a potent and specific α7 nicotinic receptor (α7 nAChR) agonist/activator with high affinity (Ki=12.3 nM) to α7 nAChRs in the human brain. |
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V70757 | Nereistoxin (Nereistoxine) | 1631-58-9 | Nereistoxin (Nereistoxine) is a neurotoxin extracted from the marine annelid Lumbriconereis heteropoda that acts by blocking nicotinic acetylcholine receptors. |
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V5093 | NS 1738 (NSC 213859) | 501684-93-1 | NS 1738 (also known as NSC 213859) is a novel and potent positive allosteric modulator of the α7 nAChR, with respect to positive modulation of nicotinic alpha7 receptor (α7 nAChR) with EC50of 3.4 μM in oocyte experiments. |
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V26678 | NS3861 | 216853-60-0 | NS-3861 is a novel and potent α3β2 nAChRfull agonist and an α3β4 partial agonist (Ki = 0.62 nM). |
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V70712 | NS3861 | 216853-59-7 | NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) with high affinity for α3β4 nAChR. |
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V70754 | PHA 568487 | 527680-57-5 | PHA 568487 is a selective agonist of the alpha-7 nicotinic acetylcholine receptor (α-7 nAchR). |
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V70748 | PHA 568487 free base | 527680-56-4 | PHA 568487 free base is a selective α-7 nicotinic acetylcholine receptor (α-7 nAchR) agonist. |
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V70722 | PHA-543613 dihydrochloride | 478148-58-2 | PHA-543613 di-HCl is a potent, orally bioactive, BBB (blood-brain barrier) crossing, and selective α7 nAChR agonist/activator with Ki of 8.8 nM. |
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V29474 | PNU-282987 S enantiomer free base | 737727-12-7 | PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987. |
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V2411 | PNU282987 freebase | 711085-63-1 | PNU282987 isa novel selective agonist of the alpha7 nAChR, evoked whole-cell currents from cultured rat hippocampal neurons that were sensitive to the selective alpha7 nAChR antagonist methyllycaconitine (MLA) and enhanced GABAergic synaptic activity when applied to hippocampal slices. |
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V81202 | Proadrenomedullin (N-20) (bovine, porcine) (ProADM N20(bovine, porcine); PAMP-20(bovine, porcine)) | Proadrenomedullin (N-20) (ProADM N20) (bovine, porcine) is a potent, noncompetitive antihypertensive and catecholamine release inhibitory peptide released from chromaffin cells. | |
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V70727 | PSEM 89S TFA | 1336913-03-1 | PSEM 89S TFA is a selective, BBB (blood-brain barrier) permeable (penetrable) agonist of ion channels produced. |
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V30868 | Pyrantel tartrate | 33401-94-4 | Pyrantel tartrate, thetartrate salt of pyrantel, is a potent antinematodal and anthelmintic agentwith a broad spectrum of activities. |
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V70771 | R-(+)-Cotinine (R-(+)-Cotinine; (+)-Cotinine; (R)-Cotinine; (R)-NIH-10498) | 32162-64-4 | R-(+)-Cotinine ((+)-Cotinine) is a nicotine metabolite that lacks significant activity across a broad range of pharmacological targets. |
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V70770 | Rabies Virus Matrix Protein Fragment(RV-MAT) | 1023648-37-4 | Rabies Virus Matrix Protein Fragment (RV-MAT) is a bioactive peptide. |
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V70772 | RGH-560 | 2408799-43-7 | RGH-560(53) displays a high degree of α7 nAChR positive modulator activity and favorable physicochemical characteristics. |
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V76553 | Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) | Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) is a neuronal nicotinic receptor agonist/activator with high selectivity for the α4β2 subtype, with a Ki of 26 nM and a Ki of 26 nM for the α7 receptor. | |
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V70762 | RJR-2429 dihydrochloride | 1021418-53-0 | RJR-2429 (diHCl) is an α4β2 and α7 nAChR agonist. |
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V2474 | SEN-12333 | 874450-44-9 | SEN 12333（also known as WAY-31753）, is a novel,potent and selective agonist of the alpha(7) nAChR (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs). |
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V70778 | SIB-1508Y | 192231-16-6 | SIB-1508Y is an orally bioactive, selective nAChR agonist. |
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