| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
Flupyradifurone targets nicotinic acetylcholine receptors (nAChRs). As an agonist, it binds to and activates these receptors, leading to overstimulation and disruption of the insect nervous system. It is effective against pests and has a favorable profile for pollinators.
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| ln Vitro |
Insect nAChRs are activated by the butenolide pesticide flupyradifurone. the poisonous end point is caused by the modification of the insect nAChR[2].
In vitro, Flupyradifurone acts as a nAChR agonist. Its activity is typically characterized in insect cell lines or tissues expressing nAChRs. The compound's potency and efficacy are determined by measuring its ability to activate the receptor and its effects on neuronal signaling in target pests. |
| ln Vivo |
In peppers, flupyradifurone has a half-life of 2.6–3.8 days. 0.00094 mg/kg is the estimated daily consumption of flupyradifurone in the country[3].
In vivo, Flupyradifurone is used as an insecticide. It is applied to crops to control sucking pests. Its systemic properties allow it to be taken up by the plant and distributed throughout its tissues, providing protection against pests that feed on the plant. Its low toxicity to bees is a key advantage over some other insecticides. |
| Enzyme Assay |
Non-cell-based assays for Flupyradifurone involve studying its binding to nAChRs. Radioligand binding studies using membrane preparations from insect tissues can be used to determine its affinity for the receptor. Its selectivity for insect nAChRs over mammalian nAChRs can also be assessed.
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| Cell Assay |
For in vitro cellular assays, insect cell lines expressing nAChRs are used. The compound's agonist activity is measured by assessing its ability to induce calcium influx or by using electrophysiological recordings. This helps to confirm its mechanism of action and potency at the receptor level.
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| Animal Protocol |
In vivo animal studies for Flupyradifurone are typically efficacy and toxicity studies in insects and non-target organisms. Its efficacy is tested against target pests in greenhouse and field trials. Its toxicity to beneficial insects like bees and other non-target organisms is also thoroughly evaluated to ensure its safety for use in agriculture.
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| ADME/Pharmacokinetics |
Flupyradifurone has a molecular weight of 288.68 g/mol and a molecular formula of C12H11ClF2N2O2. Its CAS number is 951659-40-8. It is a systemic insecticide and is available as an analytical standard and for research use. It should be stored under recommended conditions.
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| Toxicity/Toxicokinetics |
The toxicity profile of Flupyradifurone is characterized by its low toxicity to mammals and pollinators like bees. This favorable safety profile is a key feature of its development as an insecticide. It is toxic to target insects due to its action on their nAChRs. Flupyradifurone is not for human use.
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| References |
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| Additional Infomation |
Flupyradifurone is a tertiary amine compound with an ammonia-like structure, wherein the nitrogen atom is replaced by (6-chloropyridin-3-yl)methyl, 2,2-difluoroethyl, and 5-oxo-2,5-dihydrofuran-3-yl. It is a nicotinic acetylcholine receptor (AChR) agonist and can be used as an insecticide to control piercing-sucking pests on various crops. It is both an insecticide and a nicotinic acetylcholine receptor agonist. It is an organofluorine insecticide, a monochloropyridine compound, an enamine compound, a butenolide compound, and a tertiary amine compound. It possesses insecticidal activity; its structure is described in the first source.
Flupyradifurone (CAS#: 951659-40-8) is a novel insecticide that acts as a nAChR agonist. Its low toxicity to pollinators, particularly honeybees, distinguishes it from many other insecticides. It is used in agriculture to control a broad spectrum of pests and is a key tool in integrated pest management strategies. |
| Molecular Formula |
C12H11CLF2N2O2
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|---|---|
| Molecular Weight |
288.68
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| Exact Mass |
288.048
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| CAS # |
951659-40-8
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| PubChem CID |
16752772
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| Appearance |
White to off-white solid powder
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| Melting Point |
69°C(lit.)
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| LogP |
2.242
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
19
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| Complexity |
366
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1C(=CC(=O)O1)N(CC2=CN=C(C=C2)Cl)CC(F)F
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| InChi Key |
QOIYTRGFOFZNKF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C12H11ClF2N2O2/c13-10-2-1-8(4-16-10)5-17(6-11(14)15)9-3-12(18)19-7-9/h1-4,11H,5-7H2
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| Chemical Name |
3-[(6-chloropyridin-3-yl)methyl-(2,2-difluoroethyl)amino]-2H-furan-5-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (346.40 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.66 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.66 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (8.66 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4640 mL | 17.3202 mL | 34.6404 mL | |
| 5 mM | 0.6928 mL | 3.4640 mL | 6.9281 mL | |
| 10 mM | 0.3464 mL | 1.7320 mL | 3.4640 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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