Nicotinic acetylcholine receptors, or nAChRs, are proteins on neurons that signal when a chemical stimulus causes muscles to contract. On the presynaptic and postsynaptic sides of the neuromuscular junction, as well as in the plasma membranes of some neurons, they are cholinergic receptors that create ligand-gated ion channels. The most extensively researched ionotropic receptors are those for nicotinic acetylcholine. The neurotransmitter acetylcholine (ACh) binds to the nAChR, just like it does with the other type of acetylcholine receptor, the muscarinic acetylcholine receptor (mAChR). Nicotinic receptors can be opened by both acetylcholine and nicotine, hence the name "nicotinic," just as muscarinic receptors are so named because they are also activated by muscarine.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70282 | APS3 | 1225373-70-5 | APS3 is an inhibitor (blocker/antagonist) of GABA and nACh receptors, with LC50 value of 7.2423 μg/mL for diamondback moth. |
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V11709 | Asoxime chloride | 34433-31-3 | Asoxime chloride (also known as HI-6; HI6)is a potent oxime reactivator agent that can be used for counteracting intoxication by nerve agents. |
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V77238 | Asoxime-d4 dichloride (HI-6-d4) | Asoxime-d4 (dichloride) is the deuterated form of Asoxime dichloride. | |
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V2007 | Atracurium Besylate (BW-33A) | 64228-81-5 | Atracurium Besylate (also called BW 33A, 51W89)is a neuromuscular blocking agent that acts as a nondepolarizing, skeletal muscle relaxant with ED95 of 0.2 mg/kg. |
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V11955 | AVL-3288 (CCMI) | 917837-54-8 | AVL-3288 (UCI-4083; UCI4083;CCMI; XY-4083; Anvylic-3288; AVL3288) is an orally bioavailable and selective allosteric modulator of the α7 nicotinic acetylcholine receptor (α7 nAChR) with neuroprotective effects. |
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V70766 | Azemiopsin | 1391936-86-9 | Azemiopsin is a potent nicotinic acetylcholine receptor (nAChR) inhibitor (antagonist) with IC50s of 0.18 μM and 22 μM for T. californica nAChR and human α7 nAChR, respectively. |
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V77212 | Benzethonium-d7 chloride (Benzethonium d7 (chloride)) | Benzethonium-d7 chloride is the deuterated form of Benzethonium chloride. | |
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V78374 | Benzoquinonium dibromide | Benzoquinonium dibromide is an antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 of 0.46 μM. | |
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V78467 | Biotin-α-Bungarotoxin | Biotin-α-Bungarotoxin is Biotin-labeled α-Bungarotoxin. | |
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V70723 | Br-PBTC | 1839519-57-1 | Br-PBTC is a potent, subtype 2/4-selective PAM (positive allosteric modulator) of nAChRs (nicotinic acetylcholine receptors) α2β2, α2β4, α4β2, α4β4, (α4β2)2α4 and (α4β2)2β2 EC50 range is 0.1~0.6 μM. |
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V70707 | Bradanicline (TC-5619) | 639489-84-2 | Bradanicline is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist (EC50=17 nM; Ki= 1.4 nM for human α7 nAChR). |
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V70715 | Bupropion morpholinol | 357399-43-0 | Bupropion morpholinol (Hydroxy Bupropion) is the major metabolite of Bupropion. |
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V70741 | Catestatin | 142211-96-9 | Catestatin is a cationic hydrophobic peptide containing 21 amino acid (AA) residues. |
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V77165 | Catestatin TFA | Catestatin TFA is a cationic hydrophobic peptide containing 21 amino acid (AA) residues. | |
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V70777 | COG 133 | 514200-66-9 | COG 133 is a fragment of the apolipoprotein E (APOE) peptide. |
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V70702 | COG 133 TFA | 2828432-37-5 | COG 133 TFA is a fragment of the apolipoprotein E (APOE) peptide. |
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V70740 | CVN417 | 2919851-73-1 | CVN417 is an orally bioactive, α6-subunit-containing nAChR antagonist that modulates phasic dopaminergic neurotransmission in a pulse-dependent manner. |
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V70736 | Dicloromezotiaz | 1263629-39-5 | Dicloromezotiaz is a potent insecticide that acts on nicotinic acetylcholine receptors. |
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V77082 | Dinotefuran-d3 (MTI-446-d3) | Dinotefuran-d3 is the deuterated form of Dinotefuran. | |
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V79206 | DPNB-ABT594 | DPNB-ABT594 is a nitrobenzyl cage-modified ABT594, which has better selectivity for the α4β2 subtype of nAChR than the α7 subtype. |
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