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      Triflusal (UR1501)
      Triflusal (UR1501)

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V1067
      CAS #: 322-79-2 Purity ≥98%

      Description: Triflusal (formerly UR1501; Disgren, Grendis, Aflen, Triflux), a platelet aggregation inhibitor and a salicylate analog, acts by irreversibly inhibiting the production of thromboxane-B2 in platelets via acetylating the enzyme COX-1/cycloxygenase-1. The main metabolite of Triflusal is HTB, which preserves 6-keto-PGF1α synthesis in porcine aortic endothelial cells (PAEC) cells without a significant decline for up to 24 h even at the higher concentration. Triflusal at 10 mM, 100 mM and 1 M decreases LDH efflux in rat brain slices after anoxia/reoxygenation by 24%, 35% and 49% respectively. Triflusal also reduces inducible NO synthase activity by 18%, 21% and 30%.

      References: J Thromb Haemost. 2008 Aug;6(8):1385-92; Eur J Clin Invest. 2000 Sep;30(9):811-7.

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      Molecular Weight (MW)248.16 
      FormulaC10H7F3O4 
      CAS No.322-79-2 
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 50 mg/mL (201.5 mM)
      Water: <1 mg/mL
      Ethanol: 50 mg/mL (201.5 mM)
      Other info

      Chemical Name: 2-acetyloxy-4-(trifluoromethyl)benzoic acid

      InChi Key: RMWVZGDJPAKBDE-UHFFFAOYSA-N

      InChi Code: InChI=1S/C10H7F3O4/c1-5(14)17-8-4-6(10(11,12)13)2-3-7(8)9(15)16/h2-4H,1H3,(H,15,16)

      SMILES Code: O=C(O)C1=CC=C(C(F)(F)F)C=C1OC(C)=O

      SynonymsUR-1501; Triflusal, Disgren, UR1501; UR 1501; Grendis, Aflen, Triflux


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      In Vitro

      In vitro activity: The main Triflusal metabolite, HTB, preserves 6-keto-PGF1α synthesis in porcine aortic endothelial cells (PAEC) cells without a significant decline for up to 24 h even at the higher concentration. Triflusal at 10 mM, 100 mM and 1 M decreases LDH efflux in rat brain slices after anoxia/reoxygenation by 24%, 35% and 49% respectively. Triflusal also reduces inducible NO synthase activity by 18%, 21% and 30%.

      In VivoTriflusal (10 mg/kg i.v.) reduces platelet deposition on subendothelium-induced primary thrombus by about 68% in rabbits. Triflusal (10 mg/kg i.v.) reduces platelet deposition on a fresh thrombus formed over tunica media by about 48% in rabbits. Triflusal (40 mg/kg p.o.) reduces platelet deposition on a primary thrombus triggered by subendothelium and tunica media by 53% in rabbits. Triflusal (40 mg/kg p.o.) significantly reduces Cox-2 mRNA levels and protein levels without influence Cox-1 mRNA levels on the vascular wall in rabbits. Triflusal (600 mg/day for 5 days) results in an increase in NO production by neutrophils and an increase in endothelial nitric oxide synthase (eNOS) protein expression in neutrophils in healthy volunteers. Triflusal (300 mg, twice-daily orally) shows a more important increase in total walking distance and in pain-free walking distance over the basal values than those treated with placebo, together with an improvement of the symptomatology correlated with claudication in patients with chronic peripheral arteriopathy. Triflusal (300 mg, twice-daily orally) shows an increase in the peak-flow recorded through strain-gauge plethysmography in patients with chronic peripheral arteriopathy. Triflusal (30 mg/kg) strongly decreases iNOS immunolabeling at both survival times analyzed, attenuating iNOS immunoreactivity in astroglial cells and infiltrated neutrophils in rats. Triflusal (30 mg/kg) decreases neuronal and microglial COX-2 expression at 10 and 24 hours after lesion and microglial and astroglial expression of IL-1beta and TNF-alpha at 24 hours after lesion in rats. 
      Animal modelRabbits
      Formulation & Dosage10 mg/kg i.v.
      References

      J Thromb Haemost. 2008 Aug;6(8):1385-92; Eur J Clin Invest. 2000 Sep;30(9):811-7. 

      These protocols are for reference only. InvivoChem does not independently validate these methods.

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