Size | Price | Stock | Qty |
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500mg |
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1g |
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2g |
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5g |
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10g |
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Other Sizes |
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Purity: ≥98%
Flunixin Meglumin (Banamine; Flumeglumine; Flunixin-S), a non-steroidal anti-inflammatory drug (NSAID), is a potent inhibitor of the enzyme COX-cyclooxygenase with analgesic, anti-inflammatory and antipyretic activities. Flunixin meglumine is alsoa non-narcotic and non-steroidal analgesic agent with antipyretic activity. In addition, Flunixin meglumine may be used as a drug in animals for the management of intestinal ischaemia, colic, and endotoxemia.
ln Vitro |
In RAW 264.7 murine macrophages, flunixin meglumine (10-1000 μM, 2 h) suppresses the activity of inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide (LPS)[2]. In RAW 264.7 murine macrophages, lipopolysaccharide-induced activation of nuclear factor kappa B (NfκB) is inhibited by flunixin meglumine (10-1000 μM, 2 h)[2].
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ln Vivo |
Treatment with flunixin meglumine (intravenous injection; 1.1 mg/kg; once) decreases the production of serum TXB2 and exudate PGE2[1].
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Cell Assay |
Cell Viability Assay[2]
Cell Types: RAW 264.7 murine macrophages Tested Concentrations: 10, 100, 300, and 1000 μM Incubation Duration: 2 hrs (hours) Experimental Results: Inhibited LPS-induced nitric oxide release at concentrations between 100 and 1,000 µM (P=0.01). |
Animal Protocol |
Animal/Disease Models: Male sheep injected with Carrageenan[1]
Doses: 1.1 mg/kg Route of Administration: intravenous (iv) injection; 1.1 mg/kg; once Experimental Results: Inhibited Carrageenan-induced exudate PGE2 formation (Emax, 100%, IC50, <0.4 nM) and serum TXB2 generation (Emax, 100%, IC50, 17 nM) for up to 32 h. |
References |
[1]. Z Cheng, et al. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998 Aug;22(4):353-66.
[2]. Clare E Bryant, et al. Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res. 2003 Feb;64(2):211-5. |
Molecular Formula |
C14H11F3N2O2.C7H17NO5
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Molecular Weight |
491.46
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CAS # |
42461-84-7
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SMILES |
CC1=C(C=CC=C1C(F)(F)F)NC(N=CC=C2)=C2C(O)=O.O[C@H]([C@@H](O)CNC)[C@H](O)[C@H](O)CO
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InChi Key |
MGCCHNLNRBULBU-WZTVWXICSA-N
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InChi Code |
InChI=1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
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Chemical Name |
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinate
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.0348 mL | 10.1738 mL | 20.3475 mL | |
5 mM | 0.4070 mL | 2.0348 mL | 4.0695 mL | |
10 mM | 0.2035 mL | 1.0174 mL | 2.0348 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.