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    Flunixin Meglumin
    Flunixin Meglumin

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1061
    CAS #: 42461-84-7Purity ≥98%

    Description: Flunixin Meglumin (Banamine; Flumeglumine; Flunixin-S), a non-steroidal anti-inflammatory drug (NSAID), is a potent inhibitor of the enzyme COX-cyclooxygenase with analgesic, anti-inflammatory and antipyretic activities. Flunixin meglumine is alsoa non-narcotic and non-steroidal analgesic agent with antipyretic activity. In addition, Flunixin meglumine may be used as a drug in animals for the management of intestinal ischaemia, colic, and endotoxemia.

    References: J Pharmacol Exp Ther. 1977 Mar;200(3):501-7.

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    Molecular Weight (MW)491.46 
    CAS No.42461-84-7 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 98 mg/mL (199.4 mM) 
    Water: 98 mg/mL (199.4 mM)
    Ethanol: 8 mg/mL (16.3 mM) 
    Other info

    Chemical Name: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinate


    InChi Code: InChI=1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

    SMILES Code: O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2C)O.O[[email protected]]([[email protected]]([[email protected]@H]([[email protected]@H](CO)O)O)O)CNC


    Banamine; Flumeglumine; Flunixin meglumine; Flunixin-S

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    In Vitro

    In vitro activity: An in vitro whole blood model in feedlot calves was adopted to detect the activity of the anti-inflammatory agents Flunixin-meglumine (FLU), RS (±) Carprofen (CPF) and S (+) CPF. The drugs all exhibited inhibitory activity on COXs, with an order of FLU > S (+) CPF > RS (±) CPF in their potency. This finding indicated that FLU was a nonselective suppressorr of bovine COXs, whereas RS (±) CPF and S (+) CPF selectively inhibited COX-2 isoenzyme.

    In VivoFindings from mice, rats and monkeys suggested Flunixin meglumine as a potent non-narcotic analgesic agent after parenteral administration. After being subcutaneous administered, this agent showed higher efficacy than pentazocine, meperidine and codeine in the rat yeast paw test. Intramuscular administration and subcutaneous administration of Flunixin meglumine had similar effects. Moreover, orally administered Flunixin meglumine also exerted analgesic and anti-inflammatory activities. Based on mice abdominal constriction test, flunixin meglumine had comparable efficacy to pentazocine and was more potent than meperidine and codeine. In primates, 10 mg/kg flunixin meglumine showed an equal efficacy to that of 0.3 mg/kg morphine. 
    Animal modelMice, rats and monkeys
    Formulation & Dosage10 mg/kg

    J Vet Pharmacol Ther. 2014 Feb;37(1):43-52; J Pharmacol Exp Ther. 1977 Mar;200(3):501-7. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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