Flunixin Meglumin

Alias:
Cat No.:V1061 Purity: ≥98%
Flunixin Meglumin (Banamine; Flumeglumine; Flunixin-S), a non-steroidal anti-inflammatory drug (NSAID), is a potent inhibitor of the enzyme COX-cyclooxygenase with analgesic, anti-inflammatory and antipyretic activities.
Flunixin Meglumin Chemical Structure CAS No.: 42461-84-7
Product category: COX
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
500mg
1g
2g
5g
10g
Other Sizes

Other Forms of Flunixin Meglumin:

  • Flunixin-d3 (flunixin meglumine-d3)
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Flunixin Meglumin (Banamine; Flumeglumine; Flunixin-S), a non-steroidal anti-inflammatory drug (NSAID), is a potent inhibitor of the enzyme COX-cyclooxygenase with analgesic, anti-inflammatory and antipyretic activities. Flunixin meglumine is alsoa non-narcotic and non-steroidal analgesic agent with antipyretic activity. In addition, Flunixin meglumine may be used as a drug in animals for the management of intestinal ischaemia, colic, and endotoxemia.

Biological Activity I Assay Protocols (From Reference)
ln Vitro
In RAW 264.7 murine macrophages, flunixin meglumine (10-1000 μM, 2 h) suppresses the activity of inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide (LPS)[2]. In RAW 264.7 murine macrophages, lipopolysaccharide-induced activation of nuclear factor kappa B (NfκB) is inhibited by flunixin meglumine (10-1000 μM, 2 h)[2].
ln Vivo
Treatment with flunixin meglumine (intravenous injection; 1.1 mg/kg; once) decreases the production of serum TXB2 and exudate PGE2[1].
Cell Assay
Cell Viability Assay[2]
Cell Types: RAW 264.7 murine macrophages
Tested Concentrations: 10, 100, 300, and 1000 μM
Incubation Duration: 2 hrs (hours)
Experimental Results: Inhibited LPS-induced nitric oxide release at concentrations between 100 and 1,000 µM (P=0.01).
Animal Protocol
Animal/Disease Models: Male sheep injected with Carrageenan[1]
Doses: 1.1 mg/kg
Route of Administration: intravenous (iv) injection; 1.1 mg/kg; once
Experimental Results: Inhibited Carrageenan-induced exudate PGE2 formation (Emax, 100%, IC50, <0.4 nM) and serum TXB2 generation (Emax, 100%, IC50, 17 nM) for up to 32 h.
References
[1]. Z Cheng, et al. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998 Aug;22(4):353-66.
[2]. Clare E Bryant, et al. Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res. 2003 Feb;64(2):211-5.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C14H11F3N2O2.C7H17NO5
Molecular Weight
491.46
CAS #
42461-84-7
SMILES
CC1=C(C=CC=C1C(F)(F)F)NC(N=CC=C2)=C2C(O)=O.O[C@H]([C@@H](O)CNC)[C@H](O)[C@H](O)CO
InChi Key
MGCCHNLNRBULBU-WZTVWXICSA-N
InChi Code
InChI=1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
Chemical Name
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinate
Synonyms

Banamine; Flumeglumine; Flunixin meglumine; Flunixin-S

Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO:98 mg/mL (199.4 mM)
Water:98 mg/mL (199.4 mM)
Ethanol:8 mg/mL (16.3 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.0348 mL 10.1738 mL 20.3475 mL
5 mM 0.4070 mL 2.0348 mL 4.0695 mL
10 mM 0.2035 mL 1.0174 mL 2.0348 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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