In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71764 | RMI-61140 | 24140-98-5 | RMI-61140 is an orally bioactive neuroleptic agent. |
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V8750 | Ropinirole (SKF-101468) | 91374-21-9 | Ropinirole HCl (formerly SKF 101468; SKF-101468A; SKF 101468A; Requip), the hydrochloride salt of ropinirole, is a potent and selective dopamine D2 receptors agonist ( Ki = 29 nM) of the non-ergoline class of medications used for PD-Parkinson's disease, RLS/restless legs syndrome and extrapyramidal symptoms. |
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V1265 | Ropinirole HCl | 91374-20-8 | Ropinirole HCl (formerly SKF 101468; SKF-101468A; SKF 101468A; Requip), the hydrochloride salt of ropinirole, is a potent and selective dopamine D2 receptors agonist ( Ki = 29 nM) of the non-ergoline class of medications used for PD-Parkinson's disease, RLS/restless legs syndrome and extrapyramidal symptoms. |
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V71765 | Ropinirole-d3 hydrochloride (SKF 101468-d3 hydrochloride) | 1329611-00-8 | Ropinirole-d3 ( HCl) is the deuterated form of Ropinirole HCl. |
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V71772 | Ropinirole-d7 hydrochloride (SKF 101468-d7 hydrochloride) | 1261396-31-9 | Ropinirole-d7 ( HCl) is the deuterated form of Ropinirole HCl. |
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V1253 | Rotigotine (N-0437; N-0923) | 99755-59-6 | Rotigotine(formerly N-0437; N-0923; N0437; N0923; trade names Neupro among others) is a potent, non-selectivefull agonist of dopamine receptor that has been approved for use in the treatment of PD/Parkinsons disease and restless legs syndrome. |
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V14007 | Rotigotine Hydrochloride | 125572-93-2 | RotigotineHydrochloride (N-0437; N-0923) is a potent, non-selective and dopamine receptor full agonist, used in the treatment of Parkinsons disease and restless legs syndrome. |
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V1264 | Rotundine | 483-14-7 | Rotundine (also called L-THP or L-tetrahydropalmatine) is a naturally occuring alkaloid isolated from Corydalis rhizoma (a traditional Chinese medicinal plant) with analgesic activity. |
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V69999 | Roxindole hydrochloride (EMD 38362) | 108050-82-4 | Roxindole HCl, an indole alkylpiperidine, is a potent agonist of dopamine autoreceptors with affinity for the D2-like isoform in the low nanomolar range. |
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V4610 | SB-277011 Dihydrochloride | 1226917-67-4 | SB-277011 dihydrochloride (also known as SB-277011A diHCl) is a novel, potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0,<5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively. |
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V71124 | SB-277011 hydrochloride (SB-277011A hydrochloride) | 215804-67-4 | SB-277011 HCl (SB-277011A HCl) is a specific, orally bioavailable and brain-penetrating dopamine D3 receptor (D3R) antagonist (inhibitor) with Kis of 10.7 nM and 10.7 nM in rodents and human D3R, respectively. |
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V4667 | SCH-23390 | 125941-87-9 | SCH 23390 hydrochloride is a novel and potentdopamine receptor antagonist withKivalues of 0.2 and 0.3 nM for the D1 and D5. |
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V2162 | SCH-23390 maleate | 87134-87-0 | SCH-23390 is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). |
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V71714 | SKF 81297 | 71636-61-8 | SKF 81297 is a potent and specific dopamine D1 receptor agonist (activator). |
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V4977 | SKF 82958 | 74115-01-8 | SKF-82958 HBr, the hydrobromide salt of SKF-81297, is a novel, potent and selective dopamine D1/D5 receptor full agonist which stimulates motor behaviour of MPTP-lesioned monkeys. |
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V71143 | SKF-83566 | 99295-33-7 | SKF-83566 is a potent, BBB (blood-brain barrier) permeable (penetrable), orally bioactive D1-like dopamine receptor antagonist. |
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V71149 | SKF-83566 hydrobromide | 108179-91-5 | SKF-83566 HBr is a potent, BBB (blood-brain barrier) permeable (penetrable), orally bioactive D1-like dopamine receptor antagonist, which can also work as a weaker competitive antagonist. |
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V1251 | SKF38393 HCl | 62717-42-4 | SKF 38393 HCl (SKF38393; SKF-38,393; SKF 38,393; SKF-38393A), the hydrochloride salt of SKF-38393, is a novel potent and selective dopamine D1 receptor agonist with IC50 of 110 nM, and the (+)-enantiomer is the active isomer. |
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V71775 | SKF83822 hydrobromide | 74115-10-9 | SKF83822 HBr is a dopamine D1 receptor agonist. |
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V71780 | Sonepiprazole (PNU-101387G; U-101387G) | 170858-33-0 | Sonepiprazole (PNU-101387G) is a selective D4 dopamine antagonist (inhibitor) with Ki of 3.6, 10.1, 5147 and 7430 nM for rD4 dopamine, hD4.2 dopamine, rD2 dopamine and histamine H1 receptors, respectively. |
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