In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1256 | Phenothiazine (NSC2037; ENT38) | 92-84-2 | Phenothiazine (NSC 2037; ENT38; ENT 38; NSC-2037) is a potent dopamine-2 (D2) receptor antagonist used as antipsychotic medications for the treatment of schizophrenia and manifestations of psychotic disorders. |
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V18902 | Pimozide | 2062-78-4 | Pimozide (R-6238; NSC-170984; Orap) is an antipsychotic drug of the diphenylbutylpiperidine class discovered y Janssen Pharmaceuticals in 1963. |
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V71773 | PNU-177864 | 250266-51-4 | PNU-177864 is a specific, orally bioactive dopamine D3 receptor antagonist. |
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V71161 | PNU-96415E | 170856-41-4 | PNU-96415E is a selective D4/5-HT2A antagonist. |
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V0046 | Pramipexole (SND-919) | 104632-26-0 | Pramipexole (also known as SND 919), an agonist of the Gαi-linked dopamine receptors D2, D3, and D4, is a potent dopamine agonist of the non-ergoline class. |
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V28566 | Pramipexole 2HCl | 104632-25-9 | Pramipexole 2HCl (also known as SND 919), an agonist of the Gαi-linked dopamine receptors D2, D3, and D4, is a potent dopamine agonist of the non-ergoline class that is used for the treatment of Parkinsons disease (PD) and restless legs syndrome (RLS). |
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V1261 | Pramipexole 2HCl Monohydrate | 191217-81-9 | Pramipexole 2HCl monohydrate (formerly known as SND 919; trade name Mirapex among others) is the dihydrochloride salt and hydrated form of of pramipexole which isa potent agonist of the Gαi-linked dopamine receptors D2, D3, and D4 with neuroprotective effects. |
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V71744 | Pramipexole-d5 (pramipexole-d5; Mirapa-d5) | 1217975-28-4 | Pramipexole-d5 is the deuterated form of Pramipexole. |
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V71746 | Pramipexole-d7-1 dihydrochloride (pramipexole hydrochloride-d7-1; mirapax hydrochloride-d7-1) | 2702798-58-9 | Pramipexole-d7-1 (di-HCl) is the deuterated form of Pramipexole di-HCl. |
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V71779 | Preclamol hydrochloride ((-)-3-PPP hydrochloride) | 88768-67-6 | Preclamol HCl ((-)-3-PPP HCl) is a selective dopamine autoreceptor agonist (activator). |
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V2707 | Prochlorperazine dimaleate salt | 84-02-6 | Prochlorperazine dimaleate (also known as Prochlorperazin, Compazine, Capazine, Stemetil), the dimaleate salt ofProchlorperazine, is a dopamine (D2) receptor antagonist that belongs to the phenothiazine class of antipsychotic agents that are used for the antiemetic treatment of nausea and vertigo. |
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V71750 | Propionylpromazine | 3568-24-9 | Propionylpromazine is a dopamine receptor DRD2 |
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V71722 | Propionylpromazine hydrochloride (Propionylpromazine hydrochloride) | 7681-67-6 | Propionylpromazine HCl (Propiopromazine HCl) is a dopamine receptor D2 (DRD2) antagonist used in Parkinson's disease (PD) research. |
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V71751 | Propionylpromazine-d6 hydrochloride (propionylpromazine d6 hydrochloride) | 1262770-67-1 | Propionylpromazine-d6 ( HCl) is the deuterium labelled form of Propionylpromazine HCl. |
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V71204 | PZ-1190 | 1852517-78-2 | PZ-1190 is a multi-target ligand of rodent serotonin and dopamine receptors with potential antipsychotic activity. |
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V71219 | Quetiapine hemifumarate-d8 (Quetiapine hemifumarate-d8) | 1435938-24-1 | Quetiapine (hemifumarate)-d8 is the deuterated form of Quetiapine hemifumarate. |
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V34121 | rac-Rotigotine Hydrochloride | 102120-99-0 | rac-Rotigotine Hydrochloride is the racemic mixture of Rotigotine (N-0437; N-0923), which is a potent, non-selective and dopamine receptor full agonist, used in the treatment of Parkinson's disease and restless legs syndrome. |
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V29135 | Raclopride (FLA-870) | 84225-95-6 | Raclopride (formerly FLA 870) is a novel, potent and selective dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively. |
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V4975 | Raclopride tartrate | 98185-20-7 | Raclopride (formerly also known as FLA 870) is a novel, potent and selective dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively. |
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V71777 | Raclopride-d5 hydrochloride (raclopride d5 (hydrochloride)) | 1217623-85-2 | Raclopride-d5 ( HCl) is the deuterated form of Raclopride. |
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