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    SKF38393 HCl
    SKF38393 HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1251
    CAS #: 62717-42-4Purity ≥98%

    Description: SKF 38393 HCl (also known as SKF-38393A) is a novel potent and selective dopamine D1 receptor agonist with IC50 of 110 nM, the (+)-enantiomer is the active isomer. Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 also demonstrated agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR.  In locally anesthetized, artificially respired, gallamine-treated rats, i.v. administration of SKF 38393 significantly altered dopamine cell activity. In these rats, firing rate increases and decreases were also observed. 

    References: Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2446-50; Eur J Pharmacol. 2007 Dec 22;577(1-3):71-7. 

    Related CAS#: 67287-49-4 (free base); 81702-42-3 (R-isomer HCl); 20012-10-6 (HBr salt); 62751-59-1 (R-isomer)

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    Molecular Weight (MW)291.77
    FormulaC16H17NO2 . HCl
    CAS No.62717-42-4 (HCl salt); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 58 mg/mL (198.8 mM)
    Water: <1 mg/mL
    Ethanol: 6 mg/mL (20.6 mM)
    SMILES Code OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Cl
    Synonyms SKF-38393; SKF 38393; SKF38393; SKF-38,393; SKF 38,393; SKF38,393; SKF-38393 HCl; SKF-38393 hydrochloride; SKF-38393A; SKF 38393A; SKF38393A


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    In Vitro

    In vitro activity: SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations.


    Kinase Assay: SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM. 

    In VivoSKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning.
    Animal modelMale Wistar rats 
    Formulation & DosageDissolved in saline; 6 mg/kg; i.p. injection
    ReferencesProc Natl Acad Sci U S A. 1995 Mar 28;92(7):2446-50; Eur J Pharmacol. 2007 Dec 22;577(1-3):71-7.  


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    SKF38393 HCl
    Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7): 2446–2450.
     
    SKF38393 HCl
    Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7): 2446–2450.
     
    SKF38393 HCl
    Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7): 2446–2450.


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