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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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Purity: ≥98%
SKF 38393 HCl (SKF38393; SKF-38,393; SKF 38,393; SKF-38393A), the hydrochloride salt of SKF-38393, is a novel potent and selective dopamine D1 receptor agonist with IC50 of 110 nM, and the (+)-enantiomer is the active isomer. Desynchronization of electroencephalogram activity in rats is associated with SKF 38393-induced agonism of the D1DR. Additionally, serotonin SR-2C (5-HT1C receptor) agonism was demonstrated by SKF 38393. D5DR is triggered by SKF 38393 HCl. The intravenous administration of SKF 38393 significantly changed the activity of dopamine cells in rats treated with gallamine and locally anesthetized. Both rises and falls in the firing rate were noted in these rats.
| Targets |
dopamine D1 receptor; D5 receptor
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| ln Vitro |
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| ln Vivo |
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| Enzyme Assay |
SKF 38393 hydrochloride is an agonist of D1 with IC50 of 110 nM.
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| Cell Assay |
Cell Line: GC cells
Concentration: 10 μmol/L Incubation Time: 1 hour Result: Induced increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells. |
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| Animal Protocol |
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| References |
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| Molecular Formula |
C16H18CLNO2
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| Molecular Weight |
291.77
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| Exact Mass |
291.1
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| Elemental Analysis |
C, 65.86; H, 6.22; Cl, 12.15; N, 4.80; O, 10.97
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| CAS # |
62717-42-4
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| Related CAS # |
SKF 38393 hydrobromide; 20012-10-6; (R)-SKF 38393 hydrochloride; 81702-42-3; 62751-59-1 (R-isomer); 67287-49-4
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| Appearance |
Solid powder
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| SMILES |
1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl
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| InChi Key |
YEWHJCLOUYPAOH-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H
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| Chemical Name |
5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;hydrochloride
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4274 mL | 17.1368 mL | 34.2736 mL | |
| 5 mM | 0.6855 mL | 3.4274 mL | 6.8547 mL | |
| 10 mM | 0.3427 mL | 1.7137 mL | 3.4274 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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