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Pramipexole (SND-919)

Alias: SND 919; SND-919; SND919; Pramipexole; Oprymea; Pramipexol; Pramipexolum
Cat No.:V0046 Purity: ≥98%
COA Product Data Instructions for use SDS
Pramipexole (also known as SND 919), an agonist of the Gαi-linked dopamine receptors D2, D3, and D4, is a potent dopamine agonist of the non-ergoline class.
Pramipexole (SND-919) Chemical Structure CAS No.: 104632-26-0
Product category: Dopamine Receptor
This product is for research use only, not for human use. We do not sell to patients.
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Other Forms of Pramipexole (SND-919):

  • Pramipexole 2HCl
  • Dexpramipexole HCl
  • Pramipexole 2HCl Monohydrate
  • Dexpramipexole
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Purity & Quality Control Documentation

Purity: ≥98%

Purity: ≥98%

COA
MSDS
NMR
COA
MSDS
NMR
Instructions
Product Description

Pramipexole (also known as SND 919), an agonist of the Gαi-linked dopamine receptors D2, D3, and D4, is a potent dopamine agonist of the non-ergoline class. It is used for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS). Pramipexole also possesses low/insignificant affinity (500-10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptor. Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

Biological Activity I Assay Protocols (From Reference)
ln Vitro

In vitro activity: Pramipexole, a chemically novel dopamine agonist used for the treatment of Parkinsons disease symptoms, possesses antioxidant activity and is neuroprotective toward substantia nigral dopamine neurons in hypoxic-ischemic and methamphetamine models. Pramipexole reduces the levels of oxygen radicals produced by methylpyridinium ion (MPP+) both when incubated with SH-SY5Y cells and when perfused into rat striatum. Pramipexole also exhibits a concentration-dependent inhibition of opening of the mitochondrial transition pore induced by calcium and phosphate or MPP+. Pramipexole decreases the levels of dopamine metabolites dose dependently, whereas striatal dopamine levels remains unchanged. Pramipexole acts in both of these models to reduce the elevated dopamine turnover and the associated elevation in hydroxyl radical production secondary to increased MAO activity that could be responsible for oxidative damage to the nigrostriatal neurons. Pramipexole (4-100 mM) significantly attenuates DA- or L-DOPA-induced cytotoxicity and apoptosis, an action which is not blocked by D3 antagonist U-99194 A or D2 antagonist raclopride. Pramipexole also protects MES 23.5 cells from hydrogen peroxide-induced cytotoxicity in a dose-dependent manner. Pramipexole can effectively inhibit the formation of melanin, an end product resulting from DA or L-DOPA oxidation in cell-free system.
ln vivo
Pramipexole (0.001-1 mg/kg s.c.) reduces exploratory locomotor activity in mice. Pramipexole (1 mg/kg, p.o.) is able to significantly reduce the increased DA turnover, but by only 16%.
Animal Protocol
0.001-1 mg/kg s.c.; 1 mg/kg, p.o.
Mice
References
Clin Ther.2006 Aug;28(8):1065-78.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C10H17N3S
Molecular Weight
211.33
CAS #
104632-26-0
Related CAS #
Pramipexole dihydrochloride;104632-25-9;Dexpramipexole dihydrochloride;104632-27-1;Pramipexole dihydrochloride hydrate;191217-81-9;Dexpramipexole;104632-28-2;Pramipexole-d5;1217975-28-4
SMILES
S1C(N([H])[H])=NC2=C1C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[H]
Chemical Name
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole
Synonyms
SND 919; SND-919; SND919; Pramipexole; Oprymea; Pramipexol; Pramipexolum
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month
Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 42 mg/mL (198.7 mM)
Water:<1 mg/mL
Ethanol:42 mg/mL (198.7 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 4.7319 mL 23.6597 mL 47.3194 mL
5 mM 0.9464 mL 4.7319 mL 9.4639 mL
10 mM 0.4732 mL 2.3660 mL 4.7319 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Working concentration： mg/mL；

Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.

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Biological Data
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