| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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Pramipexole 2HCl (also known as SND 919), an agonist of the Gαi-linked dopamine receptors D2, D3, and D4, is a potent dopamine agonist of the non-ergoline class that is used for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS). Pramipexole exhibits negligible affinity (500-10,000 nM) towards the α2-adrenergic receptor, 5-HT1A, 5-HT1B, and 5-HT1D. A partial/full agonist of the D2S, D2L, D3, and D4 receptor, pramipexole has a Ki of 3.9, 2.2, 0.5, and 5.1 nM for the D2S, D2L, D3, and D4 receptors, respectively.
| Targets |
D3 recepto ( Ki = 0.5 nM ); D2L Receptor ( Ki = 2.2 nM ); D2S Receptor ( Ki = 3.9 nM ); D4 receptor ( Ki = 5.1 nM )
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| ln Vitro |
Pramipexole dihydrochloride has a low binding affinity for D1-type receptors [1]. Pramipexole dihydrochloride (0.01-10 μM; 72 hours) increases soma cell size and dendritic structures proportionate to the dose. Pramipexole HCl reduces the toxicity caused by levodopa in cultures of the midbrain, suggesting that Pramipexole HCl may protect dopamine neurons in tissue culture [4].
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| ln Vivo |
Pramipexole hydrochloride (0.25-1 mg/kg; ip) considerably lowers the volume of the infarct in animals. Pramipexole hydrochloride enhances neurological healing. Through pathways, pramipexole hydrochloride prevents AIDS-induced cell death in stroke.
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| References |
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| Molecular Formula |
C10H19CL2N3S
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|---|---|
| Molecular Weight |
284.25
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| Exact Mass |
283.07
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| Elemental Analysis |
C, 42.25; H, 6.74; Cl, 24.95; N, 14.78; S, 11.28
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| CAS # |
104632-25-9
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| Related CAS # |
Dexpramipexole dihydrochloride; 104632-27-1; Pramipexole; 104632-26-0; Pramipexole dihydrochloride hydrate; 191217-81-9; Dexpramipexole; 104632-28-2; Pramipexole-d7 dihydrochloride; Pramipexole-d5 dihydrochloride; 1217601-58-5; Pramipexole-d7-1 dihydrochloride; 2702798-58-9
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| Appearance |
Solid powder
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| SMILES |
CCCN[C@H]1CCC2=C(C1)SC(=N2)N.Cl.Cl
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| InChi Key |
QMNWXHSYPXQFSK-KLXURFKVSA-N
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| InChi Code |
InChI=1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m0../s1
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| Chemical Name |
(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;dihydrochloride
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| Synonyms |
Pramipexole 2HCl
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~56 mg/mL (~197.0 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (351.80 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5180 mL | 17.5901 mL | 35.1803 mL | |
| 5 mM | 0.7036 mL | 3.5180 mL | 7.0361 mL | |
| 10 mM | 0.3518 mL | 1.7590 mL | 3.5180 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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