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    Clinafloxacin (AM-1091; CI-960)
    Clinafloxacin (AM-1091; CI-960)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1415
    CAS #: 105956-97-6Purity ≥98%

    Description: Clinafloxacin (also known as CI-960, PD127391, AM-1091) is a broad-spectrum fluoroquinolone class of antibiotic that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. It is a broad-spectrum antibiotic of the quinolone carboxylic acid class currently in development for intravenous and oral therapy of serious infections. Clinafloxacin is a novel fluoroquinolone  antibiotic with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. 

    References: J Clin Pharmacol. 1999 Nov;39(11):1143-50; Antimicrob Agents Chemother. 1998 Nov;42(11):2810-6.

    Related CAS #: 105956-97-6 (free base)   105956-99-8 (HCl)  

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    Molecular Weight (MW)365.79 
    FormulaC17H17ClFN3O3 
    CAS No.105956-97-6 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: (+-)-7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, monohydrochloride

    InChi Key: BMACYHMTJHBPOX-UHFFFAOYSA-N

    InChi Code: InChI=1S/C17H17ClFN3O3.ClH/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9;/h5,7-9H,1-4,6,20H2,(H,24,25);1H

    SMILES Code: c1c2c(c(c(c1F)N3CCC(C3)N)Cl)n(cc(c2=O)C(=O)O)C4CC4.Cl

    SynonymsCI-960, PD-127391, AM-1091; CI960, PD127391, AM1091; CI 960, PD 127391, AM 1091; Clinafloxacin hydrochloride; Clinafloxacin HCl; UNII-G17M59V0FY; CI 960 HCl.


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     In Vitro

    In vitro activity: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections. Clinafloxacin is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyrA nor parC quinolone resistance mutations alone have much effect on this activity. Clinafloxacin is identified as the most active fluoroquinolone against S. pneumoniae when compared with ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent.

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    References

    J Clin Pharmacol. 1999 Nov;39(11):1143-50; Antimicrob Agents Chemother. 1998 Nov;42(11):2810-6. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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