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Teniposide (VM-26)

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InvivoChem Cat #: V1406

CAS #: 29767-20-2Purity ≥98%

Description: Teniposide (VM-26; HSDB-6546; NSC-122819; CCRIS-2058; Vumon; Vehem; EPT; PTG) is a semisynthetic podophyllotoxin derivative and chemotherapeutic agent mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). It acts by forming a ternary complex with the enzyme topoisomerase II and DNA, which results in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. Teniposide acts in the late S or early G phase of the cell cycle.

References: Nucleic Acids Res. 1987 Apr 24;15(8):3455-68.

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Molecular Weight (MW)	656.65
Formula	C32H32O13S
CAS No.	29767-20-2
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 40 mg/mL (60.9 mM)
	Water: <1 mg/mL
	Ethanol: <1 mg/mL
Other info	Chemical Name: (5S,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(thiophen-2-yl)hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one InChi Key: NRUKOCRGYNPUPR-DKQCQWADSA-N InChi Code: InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23-,24-,26+,27+,28+,29+,31+,32-/m0/s1 SMILES Code: O=C1OC[[email protected]]2([H])[[email protected]](O[[email protected]]3[[email protected]](O)[[email protected]@H](O)[[email protected]]4([H])O[[email protected]](C5=CC=CS5)OC[[email protected]@]4([H])O3)C6=C(C=C7OCOC7=C6)[[email protected]](C8=CC(OC)=C(O)C(OC)=C8)[[email protected]]21[H]
Synonyms	VM26; NSC-122819; VM-26; HSDB 6546; NSC 122819; VM 26; HSDB-6546; NSC122819; HSDB6546; CCRIS 2058. Trade name: Vumon; Vehem. Abbreviations: EPT; PTG.

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Purity ≥98%
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