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    Norfloxacin (MK-0366)
    Norfloxacin (MK-0366)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1409
    CAS #: 70458-96-7Purity ≥98%

    Description: Norfloxacin (AM-715, MK 0366; MK0366; AM715, MK-366, AM 715, MK366, MK 366, Noroxin, Chibroxin) is a broad-spectrum and synthetic chemotherapeutic antibiotic approved for the treatment of UTIs-urinary tract infections. It is active against both Gram-positive and Gram-negative bacteria, and works by inhibiting DNA gyrase. Norfloxacin is used to treat common and complicated urinary tract infections. It is a first generation synthetic fluoroquinolone and is approved for the treatment of urinary tract infections, prostatitis, and sexually transmitted diseases, although it is no longer used for the latter due to bacterial resistance. 

    References: Eur Urol. 1990;17 Suppl 1:13-8; Clin Infect Dis. 2007 Apr 1;44(7):977-80

    Related CAS: 85181-48-2 (Norfloxacin glutamate); 68077-27-0 (Norfloxacin hydrochloride); 70458-96-7 (free)

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    Molecular Weight (MW)319.33 
    FormulaC16H18FN3O3 
    CAS No.70458-96-7 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 3 mg/mL (9.4 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other infoChemical Name: 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
    InChi Key: OGJPXUAPXNRGGI-UHFFFAOYSA-N
    InChi Code: InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
    SMILES Code: O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCNCC3)=C2)C1=O)O
    SynonymsMK-0366; Norfloxacin, AM-715, MK 0366; MK0366; AM715, MK-366, AM 715, MK366, MK 366, Noroxin, Chibroxin


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    In Vitro

    In vitro activity: Norfloxacin (MK-0366) is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.There are currently three approved uses in the adult population (one of which is restricted) and the other ineffective due to bacterial resistance.

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    References Clin Infect Dis. 2007 Apr 1;44(7):977-80. Epub 2007 Feb 14.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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