PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2568 | Rbin-1 (Ribozinoindole-1) | 328023-11-6 | Rbin-1 (also known as ribozinoindole-1) is a potent and specific chemical inhibitor of eukaryotic ribosome assembly. |
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V51290 | RBN-3143 | 2360853-16-1 | RBN-3143 is a new catalytic PARP14 inhibitor that is NAD+-competitive and has an IC50 of 4 nM. |
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V2480 | RBN012759 | 2360851-29-0 | RBN012759 is a potent, selective and orally bioactive PARP14 inhibitor (antagonist) with IC50 of <3 nM, 300-fold selectivity over monoPARPs and 1000-fold selectivity over polyPARPs. |
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V2573 | RHPS4 methosulfate | 390362-78-4 | RHPS4 methosulfate (also known as NSC714187) is a potent inhibitor of telomerase with submicromolar activity. |
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V13825 | RK-287107 | 2171386-10-8 | RK-287107 is a potent TNKS/TNKS2 inhibitor (IC50 = 14.4 nM) with >7000-fold selectivity against the PARP1 enzyme, which inhibits WNT-responsive TCF reporter activity and proliferation of human colorectal cancer cell line COLO-320DM. |
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V75778 | RK-582 | 2171388-28-4 | RK-582 is an orally bioavailable, spiroindoline-based selective inhibitor of tankyrase. |
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V81334 | Ru3 | Ru3 is a poly(ADP-ribose)polymerase 1 inhibitor. | |
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V3935 | Rucaparib (AG-014699) | 283173-50-2 | Rucaparib (formerly known as AG-14447; AG-014699; PF-01367338;Rubraca) is an inhibitor of PARP [(poly(ADP-Ribose) polymerase)] with anticancer effects. |
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V3936 | RUCAPARIB CAMSYLATE | 1859053-21-6 | Rucaparib CAMSYLATE (AG014699; AG14447; PF01367338; trade name: Rubraca), the CAMSYLATE salt of rucaparib, is a potent PARP inhibitor approved by FDA for the treatment of ovarian cancer. |
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V0302 | Rucaparib phosphate (AG014699; PF01367338) | 459868-92-9 | Rucaparib (formerly AG-014699 orPF-01367338; trade name:Rubraca) is apotent, tricyclic indole based, and orally bioavailable inhibitor of PARP (poly(ADP-Ribose) polymerase) with potential anticancer activity. |
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V2472 | Saruparib (AZD5305) | 2589531-76-8 | Saruparib (AZD 5305;AZD-5305; AZD5305) is a novel, potent, selective and orally bioactive PARP [Poly(ADP-ribose)polymerase-1] inhibitor with anticancer activity. |
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V41849 | Senaparib (IMP-4297) | 1401682-78-7 | Senaparib (IMP4297) is a potent, selective, orally bioavailable PARP1/2 inhibitor. |
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V51304 | SK-575-NEG | 2523017-04-9 | SK-575-NEG (compound 28) is the methylation counterpart of SK-575, which is produced by methylating the piperidine-2,6-dione amino group in SK-575 as a control compound. SK-575-NEG has an IC50 of 2.64 nM and is tightly bound to PARP1. |
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V1188 | SRT2183 | 1001908-89-9 | SRT2183 (SRT 2183; SRT-2183) is a novel and potent small-molecule activator of the sirtuin subtype1-(SIRT1, EC50 =0.36 μM) developed by Sirtris Pharmaceuticals as therapeutics for the treatment of type 2 diabetes and potentially leukemia as well. |
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V3300 | Stenoparib (E7449) | 1140964-99-3 | Stenoparib (formerlyE-7449; 2X-121) is a novel, potent and orally bioavailable dual inhibitor of PARP1/2 [nuclear enzymes poly (ADP-ribose) polymerase] and tankyrases (TNKS1/2) with anticancer activity. |
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V0304 | Talazoparib (BMN 673; MDV3800) | 1207456-01-6 | Talazoparib (formerly BMN-673 and MDV-3800; trade name: Talzenna), is a novel, highly potent andorally bioavailable PARP1/2 [poly(ADP-ribose) polymerase] inhibitor approved for cancer treatment. |
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V3866 | Talazoparib racemic | 1207456-00-5 | Talazoparib racemic (formerly known as BMN 673 and MDV 3800), the racemic mixture of talazoparib, is a potent PARP1/2 [poly(ADP-ribose) polymerase] inhibitor with favorable pharmacokinetic properties. |
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V3865 | Talazoparib tosylate | 1373431-65-2 | Talazoparib tosylate (formerly called BMN673 and MDV3800; trade name:Talzenna), the tosylate salt of talazoparib, is an inhibitor of PARP1/2 [poly(ADP-ribose) polymerase] with potential antineoplastic activity. |
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V35223 | Tankyrase-IN-3 | 938893-79-9 | Tankyrase-IN-3 is a tankyrase 1 (TNKS1) inhibitor with an IC50 value of 22 nM. |
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V78999 | Tankyrase-IN-4 | Tankyrase-IN-4 is a tankyrase 1 (TNKS1) inhibitor (antagonist) with IC50 of 0.8 nM. |
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