PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V56032 | Tankyrase-IN-5 | 1460285-69-1 | Tankyrase-IN-5 (Compound 30f), an analog of MSC2504877 (HY-123851), is an inhibitor of tankyase TNKS1 and TNKS2 with IC50 values of 2.3 nM and 7.9 nM, respectively. |
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V56027 | TNKS-2-IN-1 | 4765-59-7 | TNKS-2-IN-1 (Compound 13g) is a novel inhibitor of TNKS-2. |
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V75780 | TNKS-2-IN-2 | 2719726-91-5 | TNKS-2-IN-2 is a potent and specific inhibitor of TNKS2 with IC50 of 22 nM. |
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V56031 | TNKS1/2-IN-2 | 1498300-35-8 | TNKS1/2-IN-2 (Compound 21) is a novel tankyrase inhibitor. |
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V0202 | UPF1069 | 1048371-03-4 | UPF 1069 (UPF-1069), an isoquinolinone derivative, is a novel, potent and selective inhibitor of poly-(ADP-ribose) polymerase 2 (PARP-2)with potential neurprotective and anti-ischemic effects in vivo. |
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V0301 | Veliparib (ABT-888) | 912444-00-9 | Veliparib (also known as ABT888; ABT-888) is a novel and potent inhibitor of PARP1 and PARP2 [Poly (ADP-Ribose) Polymerase] with potential anticancer activity. |
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V4417 | Veliparib dihydrochloride | 912445-05-7 | Veliparib dihydrochloride (also known as ABT888 dihydrochloride; ABT-888 dihydrochloride) is a novel and potent inhibitor of PARP1 and PARP2 [Poly (ADP-Ribose) Polymerase] with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. |
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V41845 | Venadaparib (IDX-1197) | 1681017-83-3 | Venadaparib (IDX-1197;IDX1197) is a novel, selective and orally bioactive PARP inhibitor (IC50s = 1 ~2 nM) with anticancer activity. |
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V35140 | Venadaparib hydrochloride (IDX-1197 hydrochloride) | 1681020-60-9 | Venadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activity. |
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V51297 | Verminoside | 50932-19-9 | Verminoside is an iridoid that was isolated from Kigelia africana. |
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V81764 | YCH1899 | YCH1899 is an orally bioactive PARP inhibitor (antagonist) with IC50 of less than 0.001 nM for PARP1/2. |
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