PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death.The PARP family consists of 17 individuals. They are all very different in terms of their cell structures and functions. There is confirmed PARP activity in the following proteins: PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2). Additional genes include PARP3, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. The nucleus of the cell contains PARP. The primary responsibility is to identify and alert the enzymatic machinery responsible for SSB repair to single-strand DNA breaks (SSB).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V81047 | PARP1-IN-16 | PARP1-IN-16 (compound 12a) is a potent PARP1 inhibitor (antagonist) with IC50 of 1.89 nM. | |
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V79059 | PARP1-IN-17 | PARP1-IN-17 is a PARP-1 inhibitor (PARP-1 IC50 = 19.24 nM, PARP-2 IC50 = 32.58 nM) and can cause apoptosis. | |
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V41042 | PARP1-IN-5 | 2735645-53-9 | PARP1-IN-5 is a low-toxic, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). |
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V41043 | PARP1-IN-5 dihydrochloride | 2823308-89-8 | PARP1-IN-5 dihydrochloride is a novel inhibitor of PARP-1 (IC50 =14.7 nM). |
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V51282 | PARP1-IN-6 | 1654735-36-0 | PARP1-IN-6 is a tubulin/PARP-1 dual (bifunctional) inhibitor (antagonist) with IC50s of 0.94 and 0.48 μM respectively. |
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V51280 | PARP1-IN-7 | 2084112-75-2 | PARP1-IN-7 is an inhibitor (blocker/antagonist) of poly(ADP-ribose) polymerase-1 (PARP1) and serves as an anti-cancer compound. |
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V51275 | PARP10-IN-2 | 1042780-52-8 | PARP10-IN-2 is a novel mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. |
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V51274 | PARP10-IN-3 | 2225800-19-9 | PARP10-IN-3 is a novel mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10. |
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V75513 | PARP10/15-IN-1 | 2892065-01-7 | PARP10/15-IN-1 (compound 8l) is a potent dual (bifunctional) inhibitor of PARP10 and PARP15 with IC50s of 160 nM and 370 nM, respectively. |
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V51278 | PARP7-IN-12 | 2819700-92-8 | PARP7-IN-12 is a novel and selective inhibitor of PARP7 with an IC50 value of 7.836 nM. In cancer research, PARP7-IN-12 may be useful. |
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V51279 | PARP7-IN-14 | PARP7-IN-14 is a novel and selective inhibitor of PARP7. | |
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V75510 | PARP7-IN-15 | 2819998-97-3 | PARP7-IN-15 (Compound 18) is a PARP7 inhibitor (antagonist) with IC50 of 0.56 nM and anti-tumor activity. |
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V75509 | PARP7-IN-16 | 2435657-10-4 | PARP7-IN-16 is a specific and orally bioactive PARP-1/2/7 inhibitor (antagonist) with IC50s of 0.94, 0.87 and 0.21 nM respectively. |
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V51273 | PARP7-probe-1 | 2379390-76-6 | PARP7-probe-1 is a chemiluminescent labeled PARP7 probe. PARP7-probe-1 is an active site-binding biotinylated probe for PARP7. For studying PARP7 function, PARP7-probe-1 can be utilized. |
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V2572 | Picolinamide | 1452-77-3 | Picolinamide (2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine)is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
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V30825 | PJ34 | 344458-19-1 | PJ34 is a potent and specific PARPl/2 inhibitor (antagonist) with IC50s of 110 nM and 86 nM respectively. |
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V0311 | PJ34 HCl | 344458-15-7 | PJ34 HCl, the hydrochloride of PJ34, is a novel, potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP) with potential anticancer and neuro-protective activities. |
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V51284 | PROTAC PARP/EGFR ligand 1 | 2661609-57-8 | PROTAC PARP/EGFR ligand 1 is an active compound that can be employed with proteolytic targeting chimera (PROTAC) technology to synthesize dual PARP EGFR degraders. |
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V2565 | Psoralen (psoralene, Ficusin, Furocoumarin) | 66-97-7 | Psoralen (psoralene, Ficusin, Furocoumarin)is a naturally occurring furocoumarin isolated from Fructus Psoraleae, it intercalates with DNA, inhibiting DNA synthesis and cell division. |
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V0309 | Quinine HCl Dihydrate | 6119-47-7 | Quinine HCl dihydrate (Quinine hydrochloride dihydrate) is anovel, potentnaturally occuring compound with a variety of biological activities such as anti-malarial, antipyretic, analgesic , anti-inflammatory properties. |
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