RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V52395 | ART812 | 2607138-82-7 | ART812 is an orally available inhibitor of DNA polymerase Polθ with an IC50 value of 7.6 nM. |
|
V84215 | aTAG 2139 (CFT-2139) | 2387510-81-6 | |
|
V84774 | aTAG 4531 (CFT-4531) | 2412985-00-1 | |
|
V2746 | Azoxystrobin | 131860-33-8 | Azoxystrobin(brand name Amistar, Syngenta) is a very important andsystemic fungicide commonly used in agriculture. |
|
V78327 | AZT triphosphate TEA (3'-Azido-3'-deoxythymidine-5'-triphosphate TEA) | AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) TEA is an active triphosphate metabolite of Zidovudine (AZT). | |
|
V2700 | B02 | 1290541-46-6 | B02 (also called RAD51-IN-02)is a potent and specific inhibitor of human RAD51 with an IC50of 27.4 μM. |
|
V52362 | BAY-364 (BAY-299N) | 2097610-30-3 | BAY-364 (BAY-299N) is an inhibitor of the second bromodomain in TAF1. |
|
V51479 | BC-LI-0186 | 695207-56-8 | BC-LI-0186 is a novel Leucyl-tRNA synthetase (LRS; LeuRS) inhibitor and Ras-related GTP-binding protein D (RagD) interaction (IC50=46.11 nM). |
|
V2269 | BCH001 | 384859-58-9 | BCH001 is a quinoline analogue and a selective PAPD5 inhibitor. |
|
V1466 | Bendamustine HCl (SDX-105) | 3543-75-7 | Bendamustine HCl (formerly also called SDX-105;EP-3101; Cytostasane; DD6304600; Treanda), the hydrochloride salt of bendamustine which is a bifunctional mechlorethamine derivative, is a potent DNA-alkylating/ cross-linking / damaging agent (IC50 = 50 μM in cell-free assay) approved for cancer treatment. |
|
V55132 | Bersiporocin (DWN12088) | 2241808-52-4 | Bersiporocin is a novel and potent prolyl-tRNA synthetase inhibitor. |
|
V1437 | Blasticidin S HCl | 3513-03-9 | Blasticidin S HCl, the hydrochloride salt of Blasticidin S, is a naturally occurring nucleoside antibiotic extracted from Stretomyces girseochromogenes. |
|
V1424 | Bleomycin Sulfate | 9041-93-4 | Bleomycin Sulfate (also known as NSC125066; NSC-125066; BLEO-cell; Bleolem; Blenoxane; Blanoxan), the sulfate salt of Bleomycin, is a glycopeptide antibiotic and an anticancer agent approved for treating a variety of cancers including Hodgkin's lymphoma, non-Hodgkin's lymphoma, ovarian cancer, testicular cancer, and cervical cancer. |
|
V78484 | BLM-IN-2 | BLM-IN-2 is an inhibitor (blocker/antagonist) of Bloom's syndrome protein (BLM) with IC50 of 0.8 μM. | |
|
V1435 | BMH-21 | 896705-16-1 | BMH-21 (BMH 21; BMH21) is a novel and potent DNA intercalator with potential antineoplastic activity. |
|
V2335 | Bractoppin | 2290527-07-8 | Bractoppin is a potent and selective inhibitor of phosphopeptide recognition by the BRCA1 tBRCT domain, which selectively interrupts BRCA1 tBRCT-dependent signals evoked by DNA damage. |
|
V3852 | Branaplam (LMI070) | 1562338-42-4 | LMI-070 (Branaplam; NVS-SM1) is a potent, orally bioactive, small-molecule enhancer of SMN2 (survival of motor neuron-2) splicing that elevates full-length SMN protein and extends survival in a severe SMA mouse model. |
|
V3853 | Branaplam (LMI070) HCl | 1562338-39-9 | Branaplam HCl (LMI-070 HCl; NVS-SM1) is a potent, orally bioactive, small-molecule enhancer of SMN2 (survival of motor neuron-2) splicing that elevates full-length SMN protein and extends survival in a severe SMA mouse model. |
|
V46895 | Branaplam diHCl | 1562338-39-9 | Branaplam diHCl (LMI-070 dihydrochloride; NVS-SM1) is a potent, orally bioactive, small-molecule enhancer of SMN2 (survival of motor neuron-2) splicing that elevates full-length SMN protein and extends survival in a severe SMA mouse model. |
|
V34685 | Bromochloroacetonitrile (bromochloroacetonitrile) | 83463-62-1 | Bromochloroacetonitrile is a byproduct of water treated with chlorine that contains organic matter. |
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