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    Blasticidin S HCl
    Blasticidin S HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1437
    CAS #: 3513-03-9Purity ≥98%

    Description: Blasticidin S HCl, the hydrochloride salt of Blasticidin S, is a naturally occurring nucleoside antibiotic extracted from Stretomyces girseochromogenes. It acts as a DNA and protein synthesis inhibitor has been used in biological research for selecting transfected cells carrying bsr or BSD resistance genes.  

    Related CAS: 2079-00-7 (free base); 3513-03-9 (HCl)

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    Molecular Weight (MW)458.9 
    FormulaC17H27ClN8O5 
    CAS No.3513-03-9 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL
    Water: 91 mg/mL (198.3 mM)  
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: (2S,3S,6R)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-((R)-3-amino-5-(1-methylguanidino)pentanamido)-3,6-dihydro-2H-pyran-2-carboxylic acid hydrochloride

    InChi Key: YQXYQOXRCNEATG-ZAYJLJTISA-N

    InChi Code: InChI=1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1

    SMILES Code: O=C([[email protected]@H]1[[email protected]@H](NC(C[[email protected]](N)CCN(C(N)=N)C)=O)C=C[[email protected]](N2C=CC(N)=NC2=O)O1)O.[H]Cl

    Synonyms

    Blasticidin S HCl


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    In Vitro

    In vitro activity: Blasticidin S inhibits protein synthesis by acting on the step of peptide transfer from peptidyl-sRNA to incoming aminoacyl-sRNA. Blasticidin S also significantly inhibits DNA synthesis independent of their effect on protein synthesis. Blasticidin S kills the cells more rapidly than G418, which makes blasticidin S-resistance gene (bsr) a selectable marker for mammalian cells. Besides, Blasticidin S also efficiently binds Cu(II) ions and prevents DNA from metal-induced damage.

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    References

    J Biochem. 1966 Dec;60(6):632-42; Biochim Biophys Acta. 1977 Mar 2;475(1):14-22. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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