Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V82254 | Cannabidiorcol (O-1821; CBD-C1) | 35482-50-9 | Cannabidiorcol (CBDO, CBD-C1, O-1821) an analogue of cannabidiol with its pentyl side chain shortened to a methyl group. |
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V3172 | CBL0137 | 1197996-80-7 | CBL0137 (formerly known as Curaxin 137 or CBL-0137) is an inhibitor of the histone chaperone,FACT (facilitates chromatin transcription complex). |
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V17766 | CD40-TRAF6 inhibitor | 433249-94-6 | CD40-TRAF6 inhibitor (TRAF-STOP inhibitor 6877002) is a novel and potent inhibitor of CD40-TRAF6 protein protein interaction with the potential for treatingatherosclerosis. |
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V82284 | cis-Vitamin K1 (cis-Phylloquinone; cis-Phytomenadione) | 16033-41-3 | Cis-Vitamin K1 is an endogenously produced metabolite of Vitamin K. |
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V1935 | CORM-3 | 475473-26-8 | CORM-3 is a water-soluble carbon monoxide (CO)-releasing molecule with potent anti-inflammatory and cardioprotective activity byattenuatingNF-κB p65 nuclear translocation, reducing ROS generation and enhancing intracellular glutathione and superoxide dismutase levels. |
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V70207 | Cryptanoside A | 98570-81-1 | Cryptanoside A is a cardiac glycoside epoxide that can be extracted from the stems of Cryptolepis dubia. |
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V17235 | Curcumenol | 19431-84-6 | Curcumenol is a potent CYP3A4 inhibitor (antagonist) with IC50 of 12.6 μM. |
|
V82283 | D-Ribofuranose (D-Ribose) | 613-83-2 | D-Ribofuranose (D-Ribose) is an endogenously produced metabolite present in cerebrospinal fluid and has been used to study ribose-5-phosphate isomerase deficiency and medium-chain acylcobalt A dehydrogenase deficiency. |
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V60088 | Damascenone | 23696-85-7 | Damascenone is an active compound of Epipremnum pinnatum which has anti-inflammatory properties. E-isomer- and Z-isomer-Damascenone combine to form the compound known as damascenone. |
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V40050 | DCZ0415 | 2242470-43-3 | DCZ0415 (DCZ-0415; DCZ 0415) is a novel and highly potent TRIP13 inhibitor that is able to impair nonhomologous end joining repair and inhibits NF-κB activity. |
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V29658 | Dehydroevodiamine | 67909-49-3 | Dehydroevodiamine is a naturally occurring quinazoline alkaloid isolated from the unripe fruit of Evodia rutaecarpa (Rutaceae) with a variety of biological effects such as hypotensive, negative chronotropic, ion channel depressa. |
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V56104 | Demethyleneberberine chloride | 16705-03-6 | Demethyleneberberine chloride is a natural mitochondria-targeted antioxidant. |
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V60127 | Isodeoxyelephantopin | 29307-03-7 | Deoxyelephantopin, a naturally occurring bioactive sesquiterpene lactone from Elephantopus scaber, has demonstrated encouraging anticancer effects against a variety of cancers. |
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V82260 | Deoxythymidine-5'-triphosphate-13C10,15N2 dilithium (dTTP-13C10,15N2 dilithium) | 2483830-18-6 | Deoxythymidine-5'-triphosphate-13C10,15N2 (dTTP-13C10,15N2) dilithium is 13C and 15N labeled Deoxythymidine-5'-triphosphate . |
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V82261 | Dihydrodaidzin | 121927-96-6 | Dihydrodaidzin is an isoflavanone that can be extracted from soybeans. |
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V30628 | Eleutheroside E | 39432-56-9 | Eleutheroside E is an important component of Acanthopanax, which has anti~inflammatory and protective effects on ischemic heart. |
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V7122 | Enzymatically modified isoquercitrin | 482-35-9 | Enzymatically modified isoquercitrin, formerly known as EMIQ, is a flavonoid. |
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V8949 | Ethacrynic acid | 58-54-8 | Ethacrynic acid (MK-595; NSC-624008; NSC-85791;Hydromedin; Crinuryl; Mingit;Etacrinic acid; Otacril Reomax; Taladren; Edecrin) isa high ceiling loop diuretic acting as a Na+/K+/2Cl- cotransporter NKCC2 inhibitor. |
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V71488 | Ethacrynic acid sodium (Etacrynic acid sodium; Sodium etacrynate) | 6500-81-8 | Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. |
|
V2020 | Evodiamine | 518-17-2 | Evodiamine (d-Evodiamine;Q-100579;SC-16015; Evo; Isoevodiamine) is a naturally occuring quinazolinocarboline alkaloid extracted from the fruit of Evodiae Fructus, exhibiting moderate antiproliferative activities against various human tumor cells. |
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