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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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Enzymatically modified isoquercitrin, formerly known as EMIQ, is a flavonoid. It has been demonstrated that EMIQ, a mixture of quercetin monoglucoside and its alpha-oligoglucosides, has a significantly higher bioavailability than other forms that are currently on the market. In comparison to quercetin, EMIQ increased Cmax (peak plasma concentration) by a factor of 40 and the area under the curve by a factor of 18 in animals. Randomized placebo-controlled trials show that EMIQ supplementation significantly increased plasma concentrations in humans compared to other forms3, such as aglycone and isoquercitrin, and that allergic symptoms improved. Additionally, EMIQ has demonstrated noticeably increased biological activity, particularly in animal models of allergy and cancer.
| ln Vitro |
Hepatocytes are shielded from ethanol-induced liver damage by isoquercetin (Quercetin 3-glucoside; 5–20 μM; 24 h), which dramatically lowers ethanol-induced cytotoxicity [1]. The ethanol HepG2 is considerably reduced by isoquercetin (10 μM; loss 1 h).
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| Cell Assay |
cell viability assay [1]
Cell Types: HepG2 cells Tested Concentrations: 5 μM, 10 μM, 20 μM Incubation Duration: 24 hrs (hours) Experimental Results: Used as a positive control to cause cells ethanol-induced iNOS protein expression levels [1]. Western Blot Analysis[1] Cell Types: HepG2 Cell Tested Concentrations: 10 μM Incubation Duration: 1 hour Experimental Results: Ethanol-induced reduction of iNOS protein expression. |
| References |
[1]. Lee S, et al. Relative protective activities of quercetin, quercetin-3-glucoside, and rutin in alcohol-induced liver injury. J Food Biochem. 2019 Aug 5:e13002.
[2]. Tan C, et al. Modulation of nuclear factor-κB signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice. Am J Obstet Gynecol. 2018 Aug;219(2):197.e1-197.e8. |
| Molecular Formula |
C21H20O12
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|---|---|
| Molecular Weight |
464.3763
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| Exact Mass |
464.09547607
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| Elemental Analysis |
C, 54.32; H, 4.34; O, 41.34
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| CAS # |
482-35-9
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| Related CAS # |
482-35-9 (EMIQ);482-35-9 (Isoquercetin);17-39-5 (quercetin);
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| Appearance |
Solid
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| SMILES |
C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O
|
| InChi Key |
OVSQVDMCBVZWGM-QSOFNFLRSA-N
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| InChi Code |
InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15-,17+,18-,21+/m1/s1
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| Chemical Name |
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
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| Synonyms |
Trifoliin A; Isoquercitrin; Isoquercitroside; Trifoliin; Isohyperoside; Isotrifolin; Isotrifoliin; Isoquercitrin; iso-quercetin; Isoquercitin; Quercetin-3-O-glucoside; Quercetin-3-glucoside
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~19.23 mg/mL (~41.41 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.92 mg/mL (4.13 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 19.2 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.92 mg/mL (4.13 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 19.2 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1.92 mg/mL (4.13 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1534 mL | 10.7670 mL | 21.5341 mL | |
| 5 mM | 0.4307 mL | 2.1534 mL | 4.3068 mL | |
| 10 mM | 0.2153 mL | 1.0767 mL | 2.1534 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT02818699 | Completed | Dietary Supplement: Placebo Dietary Supplement: EMIQ |
Obese Overweight |
Tufts University | August 1, 2016 | Not Applicable |
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