| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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Purity: ≥98%
CORM-3 is a water-soluble carbon monoxide (CO)-releasing molecule with potent anti-inflammatory and cardioprotective activity by attenuatingNF-κB p65 nuclear translocation, reducing ROS generation and enhancing intracellular glutathione and superoxide dismutase levels. CORM-3, a CO-releasing molecule, can activate the soluble guanylyl cyclase to mimic the anti-allergic and anti-anaphylactic effects of heme oxygenase. According to reports, CORM-3 has an impact on cardiovascular inflammation. It lessens the in vitro model's induction of CD54 expression on EC by PMN. Both in vitro and in vivo, CORM-3 has vasoactive qualities. By controlling blood pressure and vessel tone, it exhibits significant vasodilatation.
| Targets |
NLRP3
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| ln Vitro |
CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. [1] In RAW264.7 murine macrophages, CORM-3 reduces the inflammatory response brought on by LPS. [2] Through interaction with the phosphate carrier, CORM-3 also dissociates mitochondrial respiration. [4]
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| ln Vivo |
CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. [1] In a mouse model of collagen-induced arthritis, CORM-3 (20 mg/kg i.p.) reduces cellular infiltration, joint inflammation, and degeneration. [3]
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| Animal Protocol |
WT mice (C57BL/6J male, 8e10 weeks old)
4 mg/kg. IP for 3 h before i.p. injection of E. coli LPS (10 mg/kg), and IP injection after 7-day-treatment of S0130. |
| References |
| Molecular Formula |
C5H4CLNO5RU
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| Molecular Weight |
294.61
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| CAS # |
475473-26-8
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| Related CAS # |
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| Appearance |
Solid
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| SMILES |
[CH+]=O.[CH+]=O.[CH+]=O.C(C(=O)O)[NH-].Cl[Ru]
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| Synonyms |
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 3.75 mg/mL (12.73 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 37.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 3.75 mg/mL (12.73 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 37.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: 3.75 mg/mL (12.73 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3943 mL | 16.9716 mL | 33.9432 mL | |
| 5 mM | 0.6789 mL | 3.3943 mL | 6.7886 mL | |
| 10 mM | 0.3394 mL | 1.6972 mL | 3.3943 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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