A desirable monoclonal antibody, an effective cytotoxic drug, and a suitable linker make up antibody-drug conjugates (ADCs). A suitable linker between the antibody and the cytotoxic drug creates a clear bridge, enabling the antibody to precisely deliver the cytotoxic drug to tumor sites and deliver it only to tumor cells. In addition to conjugation, the linkers preserve the stability of ADCs during their preparation, storage, and systemic circulation phases.
The linkers found in the ADCs currently undergoing clinical evaluation are primarily divided into two groups: cleavable and noncleavable. Cleavable linkers rely on internal cellular mechanisms to release the toxin, such as cytoplasmic reduction, exposure to acidic conditions in the lysosome, or cleavage by particular cellular proteases. For the release of the cytotoxic molecule with noncleavable linkers, the antibody portion of the ADC must be broken down by proteolytic enzymes while retaining the linker and the amino acid by which it was attached to the antibody.
Based on knowledge of the internalization and breakdown of the antibody-target antigen complex and a comparison of the preclinical in vitro and in vivo activities of conjugates, the choice of linker depends on the target. Additionally, because each molecule has different chemical restrictions and frequently the drug structure lends itself to a particular linker, the choice of a linker is also influenced by the type of cytotoxin used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V52755 | 1,6-Bis(mesyloxy)hexane | 4239-24-1 | 16-Bismesyloxyhexane is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V52872 | 1-Boc-azetidine-3-carboxylic acid | 142253-55-2 | 1-Boc-azetidine-3-carboxylic acid is a non-cleavable (non-degradable) ADC linker, used for the synthesis of ADCs (antibody-drug conjugates). |
|
V52873 | 1-Boc-azetidine-3-yl-methanol | 142253-56-3 | 1-Boc-azetidine-3-yl-methanol is a non-cleavable (non-degradable) ADC linker, used to synthesize ADCs (antibody-drug conjugates). |
|
V52870 | 1-Cbz-3-Hydroxyazetidine | 128117-22-6 | 1-Cbz-3-Hydroxyazetidine is a non-cleavable (non-degradable) ADC linker, used for the synthesis of antibody-drug-conjugates/ADCss (ADCs). |
|
V52869 | 1-Cbz-azetidine-3-carboxylic acid | 97628-92-7 | 1-Cbz-azetidine-3-carboxylic acid is a non-cleavable (non-degradable) ADC linker used to synthesize ADCs (antibody-drug conjugates). |
|
V52867 | 1-N-Boc-3-hydroxyazetidine | 141699-55-0 | 1-N-Boc-3-hydroxyazetidine is a non-cleavable (non-degradable) ADC linker, used for the synthesis of ADCs (antibody-drug conjugates). |
|
V54617 | 10-Undecynoyl-OSu | 1006592-57-9 | 10-Undecynoyl-OSu is a reagent for click chemistry. |
|
V34704 | 11-Azidoundecanoic acid | 118162-45-1 | 11-Azidoundecanoic acid is a chemical reagent bearing an azide (N3) moiety and is a hydrophobic biocoupling agent. |
|
V54642 | 12-Azido-dodecanoyl-OSu | 2489524-00-5 | 12-Azido-dodecanoyl-OSu is a reagent for click chemistry containing an Azide (N3) moiety. |
|
V53351 | 15-Azido-pentadecanoic acid (Azido Palmitic Acid) | 118162-46-2 | 15-Azido-pentadecanoic acid is a chemical reagent bearing an azide (N3) moiety. |
|
V54609 | 18-Azido-stearic acid | 1529763-58-3 | 18-Azido-stearic acid is a reagent for click chemistry bearing an azide (N3) moiety. |
|
V54606 | 2,4-Diisopropylphenol | 2934-05-6 | 2,4-Diisopropylphenol is a extensively used chemical reagent. |
|
V54631 | 2-Azido-adenosine | 59587-07-4 | 2-Azido-adenosine is a dot chemical reagent containing an Azide (N3) moiety. |
|
V52866 | 20-(tert-Butoxy)-20-oxoicosanoic acid | 683239-16-9 | 20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable (non-degradable) ADC linker used for the synthesis of active antibody conjugated molecules (ADCs). |
|
V52865 | 22-(tert-Butoxy)-22-oxodocosanoic acid | 1642333-05-8 | 22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable (non-degradable) ADC linker used for the synthesis of active antibody conjugated molecules (ADCs). |
|
V54612 | 3-Azido-D-alanine | 105928-88-9 | 3-Azido-D-alanine is an azide-D-alanine (D-alanine). |
|
V77327 | 3-Azido-D-alanine hydrochloride | 3-Azido-D-alanine HCl is an azide-modified D-alanine HCl. | |
|
V53020 | 3-Azidopropanol | 72320-38-8 | 3-Azidopropanol is a reagent for click chemistry bearing an azide (N3) moiety. |
|
V34783 | 3-Azidopropylamine | 88192-19-2 | 3-Azidopropylamine is a reagent for click chemistry bearing an azide (N3) moiety. |
|
V54742 | 4-(Azidomethyl)benzoic acid | 79584-03-5 | 4-(Azidomethyl)benzoic acid is a reagent for click chemistry bearing an azide (N3) moiety. |
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