1. Home
  2. Products
  3. Signaling Pathways
  4. ADC Related
  5. ADC Linker

ADC Linker

ADC Linker

A desirable monoclonal antibody, an effective cytotoxic drug, and a suitable linker make up antibody-drug conjugates (ADCs). A suitable linker between the antibody and the cytotoxic drug creates a clear bridge, enabling the antibody to precisely deliver the cytotoxic drug to tumor sites and deliver it only to tumor cells. In addition to conjugation, the linkers preserve the stability of ADCs during their preparation, storage, and systemic circulation phases.

The linkers found in the ADCs currently undergoing clinical evaluation are primarily divided into two groups: cleavable and noncleavable. Cleavable linkers rely on internal cellular mechanisms to release the toxin, such as cytoplasmic reduction, exposure to acidic conditions in the lysosome, or cleavage by particular cellular proteases. For the release of the cytotoxic molecule with noncleavable linkers, the antibody portion of the ADC must be broken down by proteolytic enzymes while retaining the linker and the amino acid by which it was attached to the antibody.

Based on knowledge of the internalization and breakdown of the antibody-target antigen complex and a comparison of the preclinical in vitro and in vivo activities of conjugates, the choice of linker depends on the target. Additionally, because each molecule has different chemical restrictions and frequently the drug structure lends itself to a particular linker, the choice of a linker is also influenced by the type of cytotoxin used.

ADC Linker related products

Structure Cat No. Product Name CAS No. Product Description
V77884 Ald-PEG23-SPDP Ald-PEG23-SPDP is a cleavable ADC (Antibody-drug conjugate) linker containing 23 PEG (polyethylene glycol) units, which may be utilized to prepare active ADC molecules.
V54570 Ald-Ph-amido-C2-nitrate 141534-26-1 Ald-Ph-amido-C2-nitrate (Example XXIVb) is a non-cleavable (non-degradable) ADC linker that may be utilized to prepare active antibody conjugated molecules (ADC).
V54578 Ald-Ph-amido-PEG1-C2-NHS ester 2101206-80-6 Ald-Ph-amido-PEG1-C2-NHS ester is a non-degradable linker containing 1 unit of PEG, which may be utilized to prepare active ADC molecules.
V54629 Ald-Ph-amido-PEG1-C2-Pfp ester 2101206-67-9 Ald-Ph-amido-PEG1-C2-Pfp ester is a non-degradable linker containing 1 unit of PEG, which may be utilized to prepare ADC molecules.
V52740 Ald-Ph-amido-PEG11-C2-NH2 1337889-01-6 Ald-Ph-amido-PEG11-C2-NH2 is a non-cleavable (non-degradable) ADC linker containing 11 PEG (polyethylene glycol) units, which may be utilized to prepare active ADC molecules.
V52739 Ald-Ph-amido-PEG11-NH-Boc 1245813-70-0 Ald-Ph-amido-PEG11-NH-Boc is a non-cleavable (non-degradable) ADC linker containing 11 PEG (polyethylene glycol) units, which may be utilized to prepare active ADC molecules.
V54614 Ald-Ph-amido-PEG2 1061569-06-9 Ald-Ph-amido-PEG2 is a non-cleavable (non-degradable) ADC linker containing 2 PEG (polyethylene glycol) units, which may be utilized to prepare active ADC molecules.
V54582 Ald-Ph-amido-PEG2-C2-Pfp ester 2101206-60-2 Ald-Ph-amido-PEG2-C2-Pfp ester is a non-degradable linker containing 2 PEG (polyethylene glycol) units, which may be utilized to prepare active ADC molecules.
V54577 Ald-Ph-amido-PEG3-C-COOH 1007215-91-9 Ald-Ph-amido-PEG3-C-COOH is a non-cleavable (non-degradable) linker for Antibody-drug conjugates (ADC).
V54531 Ald-Ph-amido-PEG3-C1-Boc 1007215-94-2 Ald-Ph-amido-PEG3-C1-Boc is an ADC linker belonging to polyethylene glycol (PEG).
V54550 Ald-Ph-amido-PEG3-C2-Pfp ester 2101206-21-5 Ald-Ph-amido-PEG3-C2-Pfp ester is a non-cleavable (non-degradable) ADC linker containing 3 PEG (polyethylene glycol) units, which may be utilized to prepare active ADC molecules.
V52738 Ald-Ph-amido-PEG3-NHS ester 2101206-32-8 Ald-Ph-amido-PEG3-NHS ester is a non-cleavable (non-degradable) ADC linker containing 3 PEG (polyethylene glycol) units, which may be utilized to prepare active ADC molecules.
V52899 Ald-Ph-NHS ester 60444-78-2 Ald-Ph-NHS ester is a non-degradable linker that may be utilized to prepare active antibody conjugate molecules (ADC).
V54691 Alkyne Cholesterol 1631985-09-5 Alkyne Cholesterol is a modified lipid and a reagent for click chemistry containing an alkyne group.
V54579 Alkyne-PEG2-iodide 1234387-33-7 Alkyne-PEG2-iodide is a reagent for click chemistry with terminal alkyne and iodinated alkyl groups.
V77274 Alkyne-PEG5-SNAP Alkyne-PEG5-SNAP is a chemical reagent containing an alkyne group.
V54554 Alkyne-SNAP 1104822-07-2 Alkyne-SNAP (compound 3) is an alkyne-coupled benzylguanine.
V54647 Alkyne-SS-COOH 2279938-29-1 Alkyne-SS-COOH is a reagent for click chemistry containing an alkyne group.
V54585 Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP 253863-34-2 Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP is a widely used cleavable (degradable) ADC (Antibody-drug conjugate) linker for Antibody-drug conjugates (ADCs).
V51402 alpha-GalNAc-TEG-N3 882873-70-3 click chemistry reagent
Contact Us
Tel: 1-708-310-1919 Fax: 1-708-557-7486 Email: sales@invivochem.com Frequently Asked Questions
Subscribe to our E-newsletter
Name
E-mail

Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved

Contact Us Back to top
Home Classify Cart Member