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    PF-05085727
    PF-05085727

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4477
    CAS #: 1415637-72-7 Purity ≥98%

    Description: PF-05085727 is a novel, highly potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM. Phosphodiesterase 2A (PDE2A) inhibitors have been reported to demonstrate in vivo activity in preclinical models of cognition. PF-05085727 effects in vivo biochemical changes commensurate with PDE2A inhibition along with behavioral and electrophysiological reversal of the effects of NMDA antagonists in rodents. This data supports the ability of PDE2A inhibitors to potentiate NMDA signaling and their further development for clinical cognition indications.

    References:  2017 Jul 13;60(13):5673-5698.


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    PF-05085727

    Name: PF-05085727
    CAS#: 1415637-72-7
    Chemical Formula: C20H18F3N7
    Exact Mass: 413.1576
    Molecular Weight: 413.4082
    Elemental Analysis: C, 58.11; H, 4.39; F, 13.79; N, 23.72
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PF-5085727; PF 5085727; PF5085727; PF-05085727; PF 05085727; PF05085727;
    IUPAC/Chemical Name: 4-(Azetidin-1-yl)-1-methyl-3-(1-methyl-5-(4-(trifluoromethyl)-phenyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidine
    InChi Key: SHAVEYUXRBIMLA-UHFFFAOYSA-N
    InChi Code: InChI=1S/C20H18F3N7/c1-28-17(12-4-6-13(7-5-12)20(21,22)23)14(10-26-28)16-15-18(29(2)27-16)24-11-25-19(15)30-8-3-9-30/h4-7,10-11H,3,8-9H2,1-2H3
    SMILES Code: FC(C1=CC=C(C2=C(C3=NN(C)C4=NC=NC(N5CCC5)=C43)C=NN2C)C=C1)(F)F


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