A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V80997 | ODN INH-1 sodium | ODN INH-1 sodium is a palindromic inhibitory oligonucleotide. | |
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V74375 | ODN M326 (CpG-ODN M326) | 557124-74-0 | ODN M326 (CpG-ODN M326) is a potent TLR9 agonist. |
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V51778 | ODN-105870 | 1965342-40-8 | ODN 105870 is a G-modified inhibitory oligonucleotide (INH-ODN) and a TLR7 coupling agent. |
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V30447 | Okanin | 484-76-4 | Okanin is the active ingredient in Coreopsis tinctoria. |
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V74365 | Paridiprubart (NI-0101) | 2641646-59-3 | Paridiprubart (NI-0101) is a humanized anti-TLR4 monoclonal antibody (mAb). |
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V76642 | Pepinh-TRIF TFA | Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TRIF signaling by interfering with TLR-TRIF interaction. | |
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V3939 | PF-4878691 | 532959-63-0 | PF-4878691 (formerly 3M-852A or IMDZQ) is a novel and potent Toll-like receptor 7 (TLR7) agonist modeled so as to dissociate its antiviral activities from its inflammatory activities. |
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V51781 | Polvitolimod | 2389988-81-0 | Polvitolimod is a potent TLR7 agonist/activator utilized in the research into cancer and infectious diseases. |
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V76615 | Poly (I:C):Kanamycin (1:1) | Poly (I:C):Kanamycin (1:1) is a mixture of poly (I:C) and kanamycin. | |
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V76614 | Poly (I:C):Kanamycin (1:1) (sodium) | Poly (I:C):Kanamycin (1:1) sodium is an equal-proportion complex of Poly (I:C) and Kanamycin. | |
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V46737 | Poly:Kanamycin | Poly:Kanamycinis a mixture of poly (I:C) and kanamycin. | |
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V74353 | polyinosinic acid | 30918-54-8 | Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. |
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V50915 | Polyinosinic-polycytidylic acid | 24939-03-5 | Polyinosinic acid (Poly(I:C)), a synthetic analog of double-stranded RNA, is a TLR-3 agonist. |
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V37712 | Polyinosinic-polycytidylic acid sodium | 42424-50-0 | Polyinosinic-polycytidylic acid sodium(Poly(I:C) sodium)is an analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors with the potential to be usedas a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. |
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V74347 | PSMα3 | 1001405-52-2 | PSMα3 is a bioactive peptide for induction of tolerogenic DCs and may be used in DC vaccination. |
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V4598 | Resatorvid | 243984-11-4 | Resatorvid (formerly also known as TAK-242) is a novel,cell-permeable and potentTLR4 (Toll-Like Receptor)signaling inhibitor with immunomodulatory and anti-inflammatory activity. |
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V1867 | Resiquimod (R848) | 144875-48-9 | Resiquimod(formerly known as R-848; S-28463; VML-600;R848, S27609)is a potent imidazoquinolinamine-based immune response modifier that acts as an agonist of the TLR 7/8 receptors (Toll-like receptor 7/8) withantiviral and antitumour activity. |
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V76547 | RS 09 TFA | RS 09 TFA is a TLR4 agonist. | |
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V51780 | Ruzotolimod | 1948241-60-8 | Ruzotolimod is a TLR7 agonist. |
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V5940 | Schaftoside | 51938-32-0 | Schaftoside is a flavonoid found in many Chinese herbal medicines, like Eleusine indica. |
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